mineralocorticoids


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Related to mineralocorticoids: Glucocorticoids

mineralocorticoids

Hormones from the outer layer (cortex) of the adrenal gland that promote retention of sodium and excretion of potassium in the urine. ALDOSTERONE is the most powerful mineralocorticoid. Compare GLUCOCORTICOIDS.

mineralocorticoids

see ADRENAL CORTICAL HORMONES.

mineralocorticoids (min´əral´ōkôr´tikoidz),

n.pl (proinflammatory hormones), adrenal corticosteroids that are active in the retention of salt and in the maintenance of life of adrenalectomized animals. Typical are deoxycorticosterone and aldosterone. Aldosterone is a natural hormone for salt retention but also has some regulatory effect on carbohydrate metabolism.
References in periodicals archive ?
The clinical symptoms of CAH directly result from either the deficiencies in mineralocorticoid or glucocorticoid production or from the overproduction of adrenal androgens.
13) High-dose estrogens may induce sodium retention and volume expansion through an interaction with mineralocorticoid receptors or effects on 11 [beta]-HSD activity.
If aldosterone is also deficient, it is replaced with oral doses of a mineralocorticoid, called fludrocortisone acetate (Florinef[R]), which is taken once a day.
Genetic deficiency of 11-[beta]-hydroxysteroid dehydrogenase type 2 (11[beta]-HSD2) leads to apparent mineralocorticoid excess and sometimes presents in adulthood.
Aldosterone ll[beta]-hydroxy- and mineralocorticoid metabolites give androsterone further information about the extent of ll[beta]-hydroxy- adrenal depletion (or lack thereof).
Chemicals and toxins, such as mineralocorticoids and derivatives, anabolic steroids, monoamine oxidase inhibitors, lead, cadmium, and bromocriptine may induce hypertension.
The cascade is made worse by the inability of the glucocorticoid system to respond to the stress caused by the absence of mineralocorticoids.
If adrenal dysfunction is more chronic, the mineralocorticoids also become weakened and it is hard to maintain enough aldosterone to keep up the blood pressure and energy.
The resulting hormone imbalances with decreased glucocorticoids and mineralocorticoids and increased 17[alpha]-hydroxyprogesterone (17-OHP) and androgens can lead to life-threatening salt-wasting crises in the newborn period and incorrect gender assignment of virilized females (1, 2).
Consequent to profound deficiency or the complete absence of activity of 21-hydroxylase, severe forms of CAH manifest as salt-wasting attributable to impaired synthesis of mineralocorticoids and glucocorticoids.
Additive therapy with a mineralocorticoid antagonist like spironolactone can provide better blood pressure control.