mimotope


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mimotope

A novel peptide sequence which immunologically mimics an antigen’s epitope and has a 3-dimensional conformation, but not sequence homology, similar to the antigenic site. Mimotopes evoke an identical antibody response, and thus are potentially useful in developing vaccines.

mimotope

, mimetope (mĭm′ŏ-tōp″) [From mim(ic) + (epi)tope]
A small peptide that elicits a stronger antibody response than the polysaccharide or nucleic acid antigen that it is designed to mimic. Polysaccharide and nucleic acid antigens are often weakly immunogenic.
References in periodicals archive ?
protobios applies a ground-breaking high-throughput antibody repertoire characterization technology mimotope variation analysis (mva) to discover new biomarkers, Develop novel multiplexed diagnostics, And empower the discovery and development of therapeutics and vaccines.
8226; Antibody Epitope Mapping Service - Mimotope Variation Analysis (MVA) based Epitope Mapping
The results of this study advance the generation of reliable and high-yield mimotope collections of HIV epitopes.
americana component previously shown to be an allergenic molecule were used to identify the MAb-bound mimotope and its phylogenic distribution.
Identification of mimotope peptides which bind to the mycotoxin deoxynivalenol-specific monoclonal antibody.
All sixty peptide sequences were analysed in mimotope database (MimoDB 2.
Protobios' novel technology platform, Mimotope Variation Analysis (MVA, patent pending), for parallel and quantitative profiling of the binding specificity, versatility and biological activity of millions of antibodies, reflects the total immune response.
These results suggested that the presentation of the mimotope was as critical as the presentation of PSA for the antigen-antibody interaction.
Using ACE for the disease diagnosis has the following advantages: the technique is economical, rapid, experimentally straightforward and versatile, and, most significantly, it is performed in homogeneous aqueous solution, so that nonspecific interactions are minimized [20-23]; peptides can be readily separated because capillary electrophoresis is a high-resolution separation technique and charge manipulation of peptide is easily achievable; to a particular disease (Lyme borreliosis, for example), with ACE, several epitope or mimotope peptides can be used to achieve reliable diagnosis (one disease, multiple probes) in solutions.
Virus-like particles of hepatitis B virus core protein containing five mimotopes of infectious bursal disease virus (IBDV) protect chickens against IBDV.
Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease," Journal of Lipid Research, vol.
Anti-free prostate-specific antigen monoclonal antibody epitopes defined by mimotopes and molecular modeling.