mimotope


Also found in: Wikipedia.

mimotope

A novel peptide sequence which immunologically mimics an antigen’s epitope and has a 3-dimensional conformation, but not sequence homology, similar to the antigenic site. Mimotopes evoke an identical antibody response, and thus are potentially useful in developing vaccines.

mimotope

, mimetope (mĭm′ŏ-tōp″) [From mim(ic) + (epi)tope]
A small peptide that elicits a stronger antibody response than the polysaccharide or nucleic acid antigen that it is designed to mimic. Polysaccharide and nucleic acid antigens are often weakly immunogenic.
References in periodicals archive ?
8226; Antibody Epitope Mapping Service - Mimotope Variation Analysis (MVA) based Epitope Mapping
americana component previously shown to be an allergenic molecule were used to identify the MAb-bound mimotope and its phylogenic distribution.
Protobios' novel technology platform, Mimotope Variation Analysis (MVA, patent pending), for parallel and quantitative profiling of the binding specificity, versatility and biological activity of millions of antibodies, reflects the total immune response.
The Alzheimer's vaccines developed by AFFiRiS are based on AFFITOME technology developed in-house, which functions using the mimotope principle.
These results suggested that the presentation of the mimotope was as critical as the presentation of PSA for the antigen-antibody interaction.
Using ACE for the disease diagnosis has the following advantages: the technique is economical, rapid, experimentally straightforward and versatile, and, most significantly, it is performed in homogeneous aqueous solution, so that nonspecific interactions are minimized [20-23]; peptides can be readily separated because capillary electrophoresis is a high-resolution separation technique and charge manipulation of peptide is easily achievable; to a particular disease (Lyme borreliosis, for example), with ACE, several epitope or mimotope peptides can be used to achieve reliable diagnosis (one disease, multiple probes) in solutions.
HYGEIA has produced and cloned a mimotope of the AgSK1 antigen that is found only in adenocarcinomas.
Global Higher Education Pty Ltd Mimotopes Pty Ltd Kaboko Mining
CBI now operates four distinct business units: (1) CBI Services, a discovery phase contract research organization; (2) Fairfax Identity Laboratories, a DNA reference business; (3) Mimotopes Pty, Ltd, Melbourne, Australia, a peptide and discovery chemistry business; and (4) Tripos Discovery Research, Ltd, Bude, UK, a medicinal and synthetic discovery chemistry business.
Among other life science consumables acquisitions in 2002 and 2003 were Fisher's purchase of Maybridge Chemical Holding and Mimotopes (see IBO 11/ 30/02); Invitrogen's purchase of Pan Vera (see IBO 2/15/03) and GE's plan to purchase Amersham Bioscience.