milbemycin

milbemycin

(mil-be-mī'sin),
A macrocyclic lactone (macrolide) antiparasiticide used for prevention of heartworm caused by Dirofilaria immitis, treatment of Toxacara canis, Toxascaris leonina, Trichuris vulpis, and Ancylostoma caninum gastrointestinal (GI) parasites in heartworm-negative dogs; also has activity against ectoparasites such as Demodex sp.; in the avermectin family; derived from 5-didehydromilbemycin moiety from Streptomyces hygroscopicus subsp. aureolacrimosis; less toxic in Collies than ivermectin; given monthly orally. In cats, labeled for Dirofilaria immitis prevention, and treatment of GI parasites TOXACARA CATI and Ancylostoma tubaformae. Enhances gamma amino butyric acid release at the presynaptic membrane resulting in parasite paralysis and death. Not effective against flukes and tapeworms.

milbemycin

a macrolone lactone, derived from Streptomyces cyanogeneus, similar to the avermectins, effective as an anthelmintic and parasiticide. Milbemycin oxime is used for the prevention of heartworm in dogs and it has found a use in the treatment of generalized demodecosis.
References in periodicals archive ?
The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, depression/lethargy, ataxia, weight loss, convulsions, weakness, and salivation.
The role of ivermectin, milbemycin, and other heartworm preventive medications commonly used in dogs and cats is unknown.
Trifexis (spinosad + milbemycin oxime, Lilly) Zyprexa (olanzapine,
White SD, Rosychuk RA, Fieseler KV: Clinicopathologic findings, sensitivity to house dust mites and efficacy of milbemycin oxime treatment of dogs with Cheyletiella sp.
The most common drugs are milbemycin oxime and ivermectin in combination with pyrantel.
Milbemycin, derived from Streptomyces, trips up the fungal gene that enables resistant fungi to "spit out" other antifungals, he said.
lufenuron and milbemycin oxime, Virbac) Strattera[sup.
Boehringer Ingelheim) Trifexis (spinosad + milbemycin oxime, Lilly)
TM)](afoxolaner and milbemycin oxime), a soft, beef-flavored chew for dogs that provides a broad spectrum of internal and external parasite control in one monthly dose.
spinosad + milbemycin oxime), today announced a partnership in which it is providing a financial contribution and product donation to Canine Assistants, an organization that trains and places service dogs.
April 20, 2012 /PRNewswire/ --Elanco Companion Animal Health announced today the launch of its new monthly reminder system that sends clients a text message when it's time to give and/or refill one of Elanco's products, Trifexis[R] (spinosad + milbemycin oxime), Comfortis[R] (spinosad) and Assurity[R] (spinetoram).
17, 2011 /PRNewswire/ -- Elanco Companion Animal Health has launched its second product in the new year with the launch of Trifexis(TM) (spinosad + milbemycin oxime), a broad-spectrum parasiticide that kills fleas and is indicated for the prevention and treatment of flea infestations, the prevention of heartworm disease and the treatment and control of adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older, and 5 pounds of body weight or greater.