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midodrine

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midodrine /mi·do·drine/ (mi´do-drēn″) a vasopressor used as the hydrochloride salt in the treatment of orthostatic hypotension.
midodrine,
a vasopressor.
indication It is used to treat orthostatic hypotension.
contraindications Factors that prohibit its use include known hypersensitivity to midodrine, severe organic heart disease, acute renal disease, urinary retention, pheochromocytoma, thyrotoxicosis, and persistent or excessive supine hypertension.
adverse effects Adverse effects include drowsiness, restlessness, headache, chills, nausea, anorexia, dry mouth, blurred vision, pruritus, piloerection, rash, urinary urgency, and supine hypertension. Common side effects are paresthesia and pain.
midodrine [mi´do-drēn″]
a vasopressor used as the hydrochloride salt in treatment of orthostatic hypotension; administered orally.
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Here, it was possible to show that the application of the relatively long acting sympathomimetics, midodrine and etilefrine lead to an increase in attentional performance in hypotensive subjects.
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Midodrine, currently the only FDA approved treatment for orthostatic hypotension, not only fails to treat the underlying cause of symptomatic NOH but is limited in its use by a pronounced side-effect profile and black box warning for supine hypertension.
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Midodrine activates arterioles and veins receptors to produce an increase in blood pressure.
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