lethal midline granuloma

(redirected from midline malignant reticulosis granuloma)

le·thal mid·line gran·u·lo·ma

1. destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; a form of lymphoma in most cases.
2. obsolete term for polymorphic reticulosis.

lethal midline granuloma

The term is now retired and of historic interest. Lethal midline granuloma was best considered a clinical syndrome rather than a specific histologic lesion, and described as a destructive lesion of the upper respiratory tract—nose, nasopharynx, palate and midface. It was either idiopathic or secondary to lymphoma, malignant histiocytosis or Wegener’s granulomatosis. Many of the lesions formerly designated as lethal midline granoma would now be called angiocentric lymphoma and angiocentric immunoproliferative lesions.

lethal midline granuloma

A condition confusing to those who read about it and often to those who write about it; LMG is best considered a clinical syndrome rather than a specific histologic lesion; LMG is a destructive lesion of the upper respiratory tract–nose, nasopharynx, palate and midface; it is either idiopathic or 2º to lymphoma, malignant histiocytosis or Wegener's granulomatosis. See Idiopathic midline destructive disease, Malignant histiocytosis, Midline granuloma, Wegener's granulomatosis.

le·thal mid·line gran·u·lo·ma

(lēthăl midlīn granyū-lōmă)
Destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; a form of lymphoma in most cases.

le·thal mid·line gran·u·lo·ma

(lēthăl midlīn granyū-lōmă)
Destruction of nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of face, orbit, and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells.