midkine


Also found in: Acronyms, Wikipedia.

midkine

A retinoic acid-responsive, heparin-binding growth factor encoded by MDK on chromosome 11p11.2, which is expressed by various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration.

Molecular pathology
Midkine is expressed in various malignances (e.g., Wilm’s tumour and neuroblastomas), suggesting a role tumour development, perhaps through angiogenesis.
References in periodicals archive ?
Cellmid holds the largest and most comprehensive portfolio of intellectual property related to the novel oncology target midkine and midkine antagonists globally.
Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis.
Pursuant to the license, Celera will be able to utilize MTY's midkine patents for the development and commercialization of diagnostic products to address a range of lung cancer-related applications, including risk assessment, early detection, differentiation, prognosis as well as monitoring of reoccurrence and disease progression and response to treatment.
Numerous clinical studies have been conducted to date validating the role of midkine in early cancer formation.
We believe that midkine could have an important role in a blood-based immunodiagnostic assay and are pleased to be able to incorporate midkine in our on-going research and validation activities towards the development of a method to detect lung cancer using a simple blood test," said Steve Ruben, Ph.
This license is a significant endorsement of the potential value of midkine for the early diagnosis, prognosis and disease management of cancer.
Data show the optimized midkine promoter is active in a broad range of tumor types -- such as liver, colon, breast, lung, pancreas, esophagus and brain tumor cells -- without toxic effects in normal cells.