middle-of-the-night awakening

(redirected from middle of the night insomnia)

middle-of-the-night awakening

Insomnia characterised by a difficulty in returning to sleep once awakened after going to sleep for the night and before getting up at one’s usual time in the morning. MOTN awakening is associated with excessive daytime sleepiness and fatigue.

Occurs in one-third of the general population at least three nights/week.

Anxiety, obstructive sleep apnoea, chronic pain, pregnancy, toilet needs, depression, bipolar disorder, obesity, hypertension, heart disease, alcohol consumption, menopause, etc.

No medication is consistently effective.
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Active pipeline product candidates include AZ-002 (Staccato alprazolam) for the management of epilepsy in patients with acute repetitive seizures and AZ-007 (Staccato zaleplon) for the treatment of patients with middle of the night insomnia.
This strategy is exemplified by our lead product Intermezzo(TM), which we are developing for the treatment of middle of the night insomnia.
75 mg demonstrated positive and highly statistically significant results in adult insomnia patients experiencing middle of the night insomnia.