middle-of-the-night awakening

(redirected from middle of the night awakening)

middle-of-the-night awakening

Insomnia characterised by a difficulty in returning to sleep once awakened after going to sleep for the night and before getting up at one’s usual time in the morning. MOTN awakening is associated with excessive daytime sleepiness and fatigue.

Frequency
Occurs in one-third of the general population at least three nights/week.

Aetiology
Anxiety, obstructive sleep apnoea, chronic pain, pregnancy, toilet needs, depression, bipolar disorder, obesity, hypertension, heart disease, alcohol consumption, menopause, etc.

Management
No medication is consistently effective.
References in periodicals archive ?
The company is developing Intermezzo as a prescription sleep aid for use as needed when a middle of the night awakening is followed by difficulty returning to sleep.
Phase 1 clinical data presented in June 2010, at the SLEEP 2010 Meeting suggests that SKP-1041 allows natural sleep induction in subjects and prevents middle of the night awakening without next-day cognitive or motor effects, thus addressing an important unmet need among insomnia sufferers.
Gary Cupit, chief executive officer of Somnus, said, "We arepleased to be awarded this cash grant to further our clinical development of a bedtime medication that addresses the needs of millions of insomnia patients who wish to control middle of the night awakening while falling asleep naturally and avoiding next-day effects.