middle molecule


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molecule

 [mol´ĕ-kūl]
a group of atoms joined by chemical bonds; the smallest amount of a substance that possesses its characteristic properties.
adhesion m's (cell adhesion m's (CAM)) cell surface glycoproteins that mediate intercell adhesion in vertebrates.
middle molecule any molecule that has an atomic mass between 350 and 2000 daltons; these accumulate in the body fluids of patients with uremia.

middle molecule

any molecule with an atomic mass between 350 and 2000 daltons. These molecules accumulate in the body fluids of patients with uremia.

middle molecule

A molecule having a size of at least 500 daltons (Da) and no more than 30,000 Da, presumed to be an endogenous poison that accumulates in the body of patients with chronic kidney disease or uremia. Clearance of these molecules is a goal of hemodialysis. Synonym: middle-molecular-weight solute
References in periodicals archive ?
Therefore as well as considering the effect middle molecules may have to play in the uraemic spectrum, other clinical issues may need to be factored into any measurement of dialysis adequacy.
Improved dialysis efficiency for both small and middle molecules
Large middle molecules may affect a range of biological functions, including inflammation and cardiovascular risk.
It is known that the accumulation of middle molecules have a negative impact on the body, as they accumulate on the membranes, leading to disruption of transport through the membrane, damage to the protein molecules, and activation of enzymes of antioxidant protection due to what is developing endogenous intoxication, leading to the development of various pathological processes the level of the reproductive system.
In this therapy, diffusion provides excellent electrolyte and metabolite control, and middle molecules such as TNF, IL-1, cytokines, and mediators of septic shock are cleared by convective transport mechanisms.