In addition, there were abundant fibrin microthrombi
within the hepatic sinusoids.
3) Side branch occlusions, distal embolization of plaques disrupted by the balloon or stent, platelet-rich microthrombi
, vasospasm, and transient ischemia due to balloon inflation are among the proposed mechanisms.
disseminate and result in vascular occlusion, tissue ischemia, and end-organ damage.
Multiple vessels demonstrated fibrinoid necrosis of the vascular wall and microthrombi
due to extensive neutrophilic vasculitis (Fig.
Most of the time, microthrombi
develop rather than macrothrombi and clinical findings may be absent without organ failure.
Vasculitis and microthrombi
formation with eventual intravascular coagulation and spreading necrosis are characteristic pathophysiological features of the infection and present clinically with quickly spreading erythema, severe pain, systemic toxicity and blistering of the skin.
TTP is a potentially lethal condition which occurs when ultra-large Von Willebrand factor (VWF) multimers cause platelet microthrombi
in arterioles and capillaries.
Coagulation activation and the formation of microthrombi
promote further ischemic insult (Yenari, Kitagawa, Leyden, & Perez-Pinzon, 2008).
2] gradient, likely by means of pulmonary vasoconstriction, microthrombi
, and/or endothelial swelling.
Disseminated intravascular coagulation, defined as capillary microthrombi
occurring in 2 or more organs, occurred in twothirds of CM cases that had extravascular pathologic signs.
In cryoglobulinemia, a histologic examination of kidney biopsies usually reveals glomerular infiltration by activated macrophages and intraluminal microthrombi
(cryoprecipitates) in vessels; immunofluorescence or electron microscopy analysis may reveal subendothelial deposits of IgM, IgG, and complement (2).
formation of microthrombi
leading to cerebral infarction and renal failure