Endothelial injury with subsequent changes in the vessel wall results in development of microthrombi
, smooth muscle proliferation and central vein stenosis.
Additional liver lesions were microabscesses (6), endothelial necrosis (5), oval cell hyperplasia (2), massive macrovacuolar steatosis with rare midzonal to random single-cell necrosis (1) (Figure 2, panel C), and fibrin microthrombi
in sinusoids (1).
are defined by the presence of thrombi with or without organization, occluding at least 1 capillary or small arteriole in the LP and/or submucosa (Figure 6, A and B).
Endothelial damage leads to tissue oedema and formation of microthrombi
, which occlude capillaries and worsen tissue ischaemia.
Scanning transmission electron microscopic examinations revealed platelet aggregation and adhesion, microthrombi
formation, and changes in cardiomyocytes.
Fragmented red cells or schistocytes (Figure 3--Slide E) often results from mechanical break-up/resealing of red cells in the periphery by microthrombi
This can result in pulmonary hypertension by mechanical obstruction, production of microthrombi
from coagulation cascades, and induction of concentric hypertrophy via inflammatory pathways [4-6].
Microangiopathic hemolytic anemia: Anemia develops as a result of mechanical damage to erythrocytes while passing through the renal capillaries obstructed with microthrombi
and fragmentation of erythrocytes.
10,11] The axonal degeneration of both myelinated and unmyelinated fibers, axon shrinkage, axonal fragmentation, and thickening of basement membrane and microthrombi
are responsible for delayed motor nerve conduction velocity, and hence the reaction time is delayed in type 2 diabetes mellitus group.
3) Side branch occlusions, distal embolization of plaques disrupted by the balloon or stent, platelet-rich microthrombi
, vasospasm, and transient ischemia due to balloon inflation are among the proposed mechanisms.
disseminate and result in vascular occlusion, tissue ischemia, and end-organ damage.
48) The inflamed capillary beds may become progressively occluded by small fibrin microthrombi
, leading to organ microcirculatory damage and cellular hypoxemia.