27) Acetaldehyde binds to microsomal enzymes
, proteins, and microtubules to form adducts.
Indeed, liver microsomal enzymes
purportedly involved in THC metabolism are differentially produced during development, with the production of adult-type enzymes occurring only several months after birth for some enzymes and with differences in activity between children and adults noted for others (2-5).
It is evident that several phytoconstituents have the ability to induce microsomal enzymes
either by accelerating the excretion of hepatotoxin or by inhibition of lipid peroxidation induced by it (10).
Although the exact mechanism for causing lactic acidosis is not understood, it is postulated that biguanides induce it by inhibiting certain microsomal enzymes
involved in glucose metabolism (3).
11beta-Hydroxysteroid dehydrogenases (11beta-HSD) are microsomal enzymes
that catalyze the conversion of active glucocorticoids (GC) to their inactive 11-dehydro products and vice versa.
The purpose of the present investigation is twofold: to group PCB congeners based on their potential to induce microsomal enzymes
in animals; and to examine the relation between neonatal TSH and prenatal exposure to PCB congeners grouped according to their structure and potential mechanisms of actions.
Effects of methylmercury hydroxide on rat liver microsomal enzymes
All hydantoins induce production of liver microsomal enzymes
(the cytochrome P-450 system), thereby accelerating the metabolism of concomitantly administered drugs.
Differential regulation of microsomal enzymes
that glucuronidate [T.
Alternatively, chlorpyrifos is dearylated to form TCPy and diethylthiophosphate (DETP) by microsomal enzymes
or by nonenzymatic hydrolysis.
Effects of PCBs on microsomal enzymes
and on synthesis and turnover of microsomal and cytoplasmic lipids.
We present here the first evidence that TCB, CCB, 1,3-diphenylpropane, and 2,4-diphenyl-1-butene are converted to metabolites with estrogenic activity by liver microsomal enzymes