A second molecular difference between articaine and other amide local anesthetics, the extra ester group in its structure allowing hydrolysis of the drug both by plasma esterases and by liver microsomal enzymes
19] Liver cyatochrome P450 enzymes are microsomal enzymes
involved in metabolism of xenobiotics, such as, toxins and steroid hormones.
27) Acetaldehyde binds to microsomal enzymes
, proteins, and microtubules to form adducts.
Indeed, liver microsomal enzymes
purportedly involved in THC metabolism are differentially produced during development, with the production of adult-type enzymes occurring only several months after birth for some enzymes and with differences in activity between children and adults noted for others (2-5).
It is evident that several phytoconstituents have the ability to induce microsomal enzymes
either by accelerating the excretion of hepatotoxin or by inhibition of lipid peroxidation induced by it (10).
Although the exact mechanism for causing lactic acidosis is not understood, it is postulated that biguanides induce it by inhibiting certain microsomal enzymes
involved in glucose metabolism (3).
11beta-Hydroxysteroid dehydrogenases (11beta-HSD) are microsomal enzymes
that catalyze the conversion of active glucocorticoids (GC) to their inactive 11-dehydro products and vice versa.
Galactose-6-phosphate showed to be a good substrate for both NE and microsomal enzymes
, with similar latency to that obtained with M-6-P using microsomes.
The purpose of the present investigation is twofold: to group PCB congeners based on their potential to induce microsomal enzymes
in animals; and to examine the relation between neonatal TSH and prenatal exposure to PCB congeners grouped according to their structure and potential mechanisms of actions.
Effects of methylmercury hydroxide on rat liver microsomal enzymes
Both chloroplast-targeted and microsomal omega-3 fatty-acid desaturases have been identified in plants, but the microsomal enzymes
have been shown to be the major contributors to seed linolenic acid levels (Yadav et al.
Piperonyl butoxide (either alone or combined with n-octyl bicycloheptene dicarboximide) often is added to pyrethrin products to inhibit microsomal enzymes
that detoxify pyrethrins .