microsomal enzyme

microsomal enzyme

Any of the catabolic drug-metabolising enzymes on the smooth endoplasmic reticulum of liver, kidneys, gastrointestinal tract.
 
Types
• UDP-Glucuronyl transferases.
• Cytochrome P450 isoforms
• Mixed-function oxidases (MFOs), which require NADPH and O2.
References in periodicals archive ?
In the adrenal cortex, this is processed into either glucocorticoids and androgens in zona fasciculate and zona reticularis (which contain the microsomal enzyme cytochrome P450c17[alpha]-hydroxylase: P450c17 and 17,20 lyase) or into mineralocorticoids in zona glomerulosa (which does not contain P450c17 and 17,20 lyase, but contains aldosterone synthase, CYP11B2).
AST is a microsomal enzyme that is found in large amounts in the liver and with destructive liver tissue, is released in the blood in large amounts [19].
During phase I metabolism, drug molecules are transformed through oxidation or reduction of hydrolysis reactions by the action of a family of enzymes called the Cytochrome P450 (CYP) or microsomal enzyme system.
DGAT is a microsomal enzyme expressed in the liver and rate-limited enzyme in the process of TG synthesis, catalyzes the final step in TG synthesis by converting diacylglycerol and fatty acylcoenzyme A into TC (Farese et a).
The microsomal system was more sensitive to N-ethylmalemide (NEM) than the NE and the latter was insensitive to anion transport inhibitors DIDS and SITS, which strongly affect the microsomal enzyme.
estrogenicity, antiestrogenicity, or microsomal enzyme induction).
We observed a linear increase in control activity with added microsomal enzyme as evidenced by accumulation of radiolabeled product.
In high therapeutic doses, nafcillin may cause hepatic microsomal enzyme induction.
Some PCB congeners reportedly induce the microsomal enzyme uridinediphosphate glucuronosyltransferase (UDP-GT), which catalyzes the glucuronidation of [T.
More often, however, the barbiturates cause a marked increase in the microsomal enzyme system to accelerate the metabolism of other drugs including the sedative-hypnotics themselves.

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