microsomal enzyme

microsomal enzyme

Any of the catabolic drug-metabolising enzymes on the smooth endoplasmic reticulum of liver, kidneys, gastrointestinal tract.
 
Types
• UDP-Glucuronyl transferases.
• Cytochrome P450 isoforms
• Mixed-function oxidases (MFOs), which require NADPH and O2.
References in periodicals archive ?
AST is a microsomal enzyme that is found in large amounts in the liver and with destructive liver tissue, is released in the blood in large amounts [19].
During phase I metabolism, drug molecules are transformed through oxidation or reduction of hydrolysis reactions by the action of a family of enzymes called the Cytochrome P450 (CYP) or microsomal enzyme system.
DGAT is a microsomal enzyme expressed in the liver and rate-limited enzyme in the process of TG synthesis, catalyzes the final step in TG synthesis by converting diacylglycerol and fatty acylcoenzyme A into TC (Farese et a).
estrogenicity, antiestrogenicity, or microsomal enzyme induction).
We observed a linear increase in control activity with added microsomal enzyme as evidenced by accumulation of radiolabeled product.
As microsomal enzyme induction associated with hepatocellular hypertrophy can pose a potential risk in drug interactions, the presence and degree of hepatocellular hypertrophy is an important consideration in drug development.
Some PCB congeners reportedly induce the microsomal enzyme uridinediphosphate glucuronosyltransferase (UDP-GT), which catalyzes the glucuronidation of [T.
5 [micro]m and contain adsorbed organic compounds, many of which are known to alter the pulmonary microsomal enzyme pool, which results in altered xenobiotic metabolism.
The hepatoprotective effect may be mediated through combination of multiple mechanisms, such as reported anti-oxidant, free radical scavenging, anti-inflammatory, calcium channel blocking and/or microsomal enzyme inhibitory action.
Differential effects of microsomal enzyme inducers on in vitrothyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation.
Results did demonstrate that TBT neither directly inhibits the ATAT enzyme responsible for the fatty acid esterification of testosterone, nor does it suppress levels of the microsomal enzyme, as determined though activity assays following in vivo exposure to TBT.

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