microscopic polyangiitis

(redirected from microscopic polyarteritis)

microscopic polyangiitis

systemic, nongranulomatous small-vessel vasculitis, associated with glomerulonephritis, pulmonary capillaritis, palpable purpura, and antineutrophil cytoplasmic autoantibodies.

microscopic polyangiitis

A systemic small-vessel vasculitis that primarily affects the kidneys, skin, and lungs of middle-aged men.

Clinical findings
Fever, malaise, myalgia, weight loss, and autoimmunity, including antineutrophil cytoplasmic antibodies (p-ANCA). Skin lesions occur in 30 to 50%, usually presenting as purpura due to leukocytoclastic vasculitis, less commonly as nodules involving the vessels of the dermis and subcutaneous fat and ulcers. The kidney shows rapidly progressive focal and segmental glomerulonephritis.

DiffDx
Polyarteritis nodosa.

microscopic polyangiitis

Hypersensitivity angiitis, microscopic periarteritis, microscopic polyarteritis Internal medicine The term recommended for necrotizing vasculitis with few or no immune deposits, affecting small vessels–ie, arterioles, capillaries, venules; MP is often accompanied by ANCA, necrotizing glomerulonephritis and pulmonary capillaritis. See Small vessel vasculitis, Systemic vasculitis.

mi·cro·scop·ic pol·y·an·gi·i·tis

(mī'krŏ-skop'ik pol'ē-an'jē-ī'tis)
Systemic, nongranulomatous small-vessel vasculitis, associated with glomerulonephritis, pulmonary capillaritis, palpable purpura, and antineutrophil cytoplasmic autoantibodies.
References in periodicals archive ?
Renal vasculitis: microscopic polyarteritis and Wegener's granuloma.
Even when a child has clinical findings that resemble "bite marks" or "ligature marks on hands and feet," missing fingernails, or tissue tears that suggest lacerations or avulsive injuries, the possibility of microscopic polyarteritis should be ruled out by tests for neutrophilia; lymphopenia; and elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), Creactive protein (CRP), and lactate dehydrogenase (LDH) before accusing the caregiver of committing a crime.
2) In general, C-ANCA is associated with WG and P-ANCA is linked to microscopic polyarteritis and Churg-Strauss syndrome.
It is most commonly associated with microscopic polyarteritis (70%) (19) but can also be seen in pauci-immune glomerulonephritis without extrarenal disease (80%) (20) and Wegener.

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