MITF

(redirected from microphthalmia transcription factor)

MITF

Microphthalmia transcription factor. A helix-loop-helix leucine zipper-type transcription factor encoded by MITF on chromosome 3p14.2-p14.1, which is involved in melanocyte and osteoclast development. MITF controls the DNA damage response, and plays a critical role in melanoma proliferation; its inhibition is associated with G0-G1 growth arrest, and lineage-specific senescence in melanomas.
References in periodicals archive ?
Both TFE3 and TFEB belong to the microphthalmia transcription factor (MiTF) subfamily.
These results suggest that, in contrast to the currently available first-generation melanocytic markers such as S100, microphthalmia transcription factor (MITF), and Martl/Melan A, (14-18) R21 immunohistochemistry can be used to distinguish melanoma from benign melanocytic proliferations and may be useful in the subclassification of melanoma.
Microphthalmia transcription factor expression in cutaneous benign, malignant melanocytic, and nonmelanocytic tumors.
Beta White multi-tasks to address both the genetic and environmental causes of a blotchy skin tone by inhibiting the microphthalmia transcription factor (MITF) pathway.
Continued patient enrollment as planned in the Phase 2 monotherapy trial with ARQ 197 in Microphthalmia Transcription Factor (MiT)-associated tumors;
Microphthalmia transcription factor (MiTF) is a nuclear protein involved in the development of melanocytes and the regulation of melanin synthesis in melanocytic lesions (13,14);it may be expressed by macrophages, lymphocytes, fibroblasts, Schwann cells, and smooth muscle cells.
7) Lymphangioleiomyomatosis cells coexpress contractile proteins (mainly [alpha]-smooth muscle actin and desmin) (Figure 5), melanocytic markers such as HMB-45, HMSA-1, MelanA/Martl, and microphthalmia transcription factor (MiTF) (Figures 6 and 7) and estrogen and progesterone receptors.
Preliminary Results from a Phase 2 Study of ARQ 197 in Patients with Microphthalmia Transcription Factor Family (MiT) Associated Tumors: Abstract Number 10502.
Microphthalmia transcription factor is necessary for the development of melanocytes during embryogenesis.
24-26) Another melanocytic marker, microphthalmia transcription factor (MiTF), has been evaluated for possible use in the differential diagnosis of DMM and other spindle cell proliferations of the skin.
Immunohistochemical studies of CCSTA show that the tumor cells express antigens associated with melanin synthesis including diffuse cytoplasmic immunoreactivity with HMB-45 (Figure 3), nuclear and cytoplasmic immunoreactivity to S100 protein (Figure 4), and reactivity with the microphthalmia transcription factor.
Expression of microphthalmia transcription factor (mitf), a nuclear regulatory protein critical for melanocytic differentiation, and expression of the tyrosinase gene, an enzyme involved in the synthesis of melanin, (2-9) has been reported in melanocytic tumors.