micropapillary urothelial carcinoma

micropapillary urothelial carcinoma

A uncommon variant of urothelial (transitional cell) carcinoma that presents in older (average age 76) adults, more commonly in men, which is histologically high grade, deeply invasive (into muscularis propria) and metastastatic, variably accompanied by in situ carcinoma.

DiffDx
Metastatic micropapillary carcinoma, papillary (e.g., renal cell) carcinoma.

Management
Immediate radical cystectomy.

Prognosis
Poor: all patients die within two years.
References in periodicals archive ?
8) A direct extension of a micropapillary urothelial carcinoma was highly unlikely.
Micropapillary urothelial carcinoma (MPUC) is a rare, clinically aggressive histologic variant of urothelial carcinoma (UC).
Micropapillary urothelial carcinoma was initially described as a histologic variant of conventional urothelial carcinoma with an aggressive clinical course.
Emerging concepts in micropapillary urothelial carcinoma.
Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases.
Neoadjuvant systemic therapy or early cystectomy: single-center analysis of outcomes after therapy for patients with clinically localized micropapillary urothelial carcinoma of the bladder.
Invasive micropapillary urothelial carcinoma of the bladder.
Micropapillary urothelial carcinoma of the upper urinary tract: clinicopathologic study of five cases.