microneme


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mi·cro·neme

(mī'krō-nēm),
A small, osmiophilic, cordlike twisted organelle found in the anterior region of many sporozoans; one of the characteristics that helps to define the subphylum Apicomplexa.
Synonym(s): sarconeme
[micro- + G. nēma, thread]
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References in periodicals archive ?
tenella and known to encode a microneme adhesion involved in parasite motility and host cell invasion by the parasite (Lillehoj et al.
1, plays a similar role in the secretion of microneme organelles that are crucial to the mobility of the parasitic protozoa Toxoplasma gondii, which causes toxoplasmosis, and Plasmodium falciparum, which causes malaria.
The mechanism of microneme secretion, which is required for host cell invasion, is a valid drug target," Gubbels said.
Since neither microneme secretion nor invasion itself are currently targeted by any anti-malaria drugs, a potentially new class of anti-malaria reagents can be developed.
1 gene that was associated with a microneme secretion defect responsible for the mobility defect.
N-terminal-tagged GST-VP1s from BKV, JCV, and simian virus 40 (SV40) were generously provided by Michael Pawlita (16), and GST-tagged microneme (Mic) protein encoded by Toxoplasma gondii was provided by David Sibley.
A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii.
TgSUB1 is a microneme protein, whereas TgSUB2 localizes to rhoptries and associates with rhoptry protein ROP1, a potential substrate.
During invasion and creation of the PV membrane, apically oriented organelles called micronemes and rhoptries are discharged, followed later by release of dense granules content (DG).
In order to invade the host cell they employ an arsenal of virulence factors derived from the specialised secretory organelles; the micronemes, rhoptries and dense granules that are sequentially secreted during the invasion process.
Our recent research has established endosomal-like compartments as a key organelle for the specific sorting to micronemes and rhoptries.
iii) Systematically dissect the pathways involved in the organisation of the endosomal-like compartments and therefore in the biogenesis, maintenance and regulation of micronemes and rhoptries;