The prototype has demonstrated a very high sensitivity to ICG in the nanomolar and micromolar
range, similar to that required to detect early stage cancers.
The EvoRx team successfully generated peptides with sub micromolar
cell activity and low drop-off from primary potency meeting the primary goal of the collaboration.
As expected, toremifene inhibited EBOV at low micromolar
and uncertainty in the results is less than 6%.
Polygodial exhibits anti-inflammatory activity at micromolar
and submicromolar concentrations in a mouse model of gout through inhibition of mono sodium urate-induced neutrophil infiltration and neutrophil superoxide production.
PSMs are small alpha-helical peptides which have two distinct functions on the immune system, in vitro PSMs can attract neutrophils in the nanomolar range, whereas in the micromolar
range they are cytolytic for neutrophils.
From this screen, only angoline (1) showed potent inhibitory effect on cell proliferation of three human cancer cells at low micromolar
She found that a high level of gamma-tocoperol, 10 micromolar
in the blood plasma, was associated with a 10 to 17 percent reduction in lung function.
Whereas picomolar concentrations of kinetin initiate the formation of caulonema initials that produce filamentous growth, micromolar
concentrations stimulate the assembly of 3dimensional buds in Funaria hygrometrica Hedwig (Schumaker and Dietrich, 1997; Bopp and Jacob, 1986).
Beneficial effects are achieved with low micromolar
levels of LA, suggesting that some of its therapeutic potential extends beyond the strict definition of an antioxidant.
concentrations for 2 hrs incubation periods, the ligand and Zn[L.
Tamoxifen in micromolar
concentrations presents cytotoxic activity not mediated by estrogen receptors in some tumoral and non tumoral cell types, including blood cells, such as neutrophils (JAN et al.