microinvasion


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microinvasion

 [mi″kro-in-va´zhun]
microscopic extension of malignant cells into adjacent tissue in carcinoma in situ. adj., adj microinva´sive.

mi·cro·in·va·sion

(mī'krō-in-vā'zhŭn),
Invasion of tissue immediately adjacent to a carcinoma in situ, the earliest stage of malignant neoplastic invasion.

microinvasion

/mi·cro·in·va·sion/ (-in-va´zhun) microscopic extension of malignant cells into adjacent tissue in carcinoma in situ.microinva´sive

microinvasion

A generic term for an epithelial malignancy in which the basement membrane has been minimally violated. As a rule, microinvasive cancers measure 1 mm or less in greatest dimension and are designated as Tmic, prognostically between T0 (carcinoma in situ) and T1a in the TNM system. It is also defined as > 1 focus of cancer measuring 2 mm or less in diameter.

mi·cro·in·va·sion

(mī'krō-in-vā'zhŭn)
Invasion of tissue immediately adjacent to a carcinoma in situ, the earliest stage of malignant neoplastic invasion.

microinvasion

microscopic extension of malignant cells into adjacent tissue.
References in periodicals archive ?
Interpretational errors include overdiagnosis of benign lesions as DCIS (for example, florid usual hyperplasia) or underdiagnosis of invasive carcinoma (for example, when microinvasion is overlooked or when invasive cribriform carcinoma is not recognized).
In addition, identification of foci of microinvasion around DCIS lesions is very important for appropriate surgical planning and ultimate patient outcome.
Microinvasion, if properly diagnosed and treated, is associated with a cure rate approaching 100% with local treatment alone, (5) so it is important to identity this early and accurately using tools such as Multiplex IHC.
Microinvasion is more common with the comedo subtype of DCIS (53% microinvasion), multicentric DCIS and DCIS presenting with a palpable mass or large size on imaging.
The remaining 3 patients had areas of microinvasion and their nodes were free of carcinoma.
ADH-5 can solve multiple clinical problems including 1) differentiating hyperplasia of the usual type from atypical ductal hyperplasia, 2) identifying microinvasion and invasive ductal carcinoma, and 3) distinguishing basal phenotypes on triple negatives.
The extent of microinvasion through the layers of the dermis was determined by the Clark and/or Breslow classification systems (36, 37).
Large biopsy is reserved for lesions showing colposcopic evidence of microinvasion, such as abnormal vascular patterns marked by corkscrewing, marked dilation, or increased intercapillary distance.
EGF increased the invasive capacity of PC-3 cells in a Boyden chamber microinvasion assay.
In a similar study, Fayanju et al (20) found that patients with IPC with associated DCIS or microinvasion more frequently undergo adjuvant radiation and endocrine therapy than patients with pure IPC.