The Intestine-Chip is a "home-away-from-home" for human cells, and provides them with the right microenvironment
and biological cues they need to behave just like they do in the body.
In results from experiments using mouse models, ONO-4578 showed an anti-tumor effect by improving immunosuppressive tumor microenvironment
Inorganic arsenic-related changes In the stromal tumor microenvironment
In a prostate cancer cell-conditioned media model.
The new study, showing that adult MuSCs living in a microenvironment
with fetal characteristics are better at regenerating muscle, provides rationale for developing drugs that could trigger this transition.
In cancer tissues and cell lines, including lung, breast, and ovarian cancer cells, Nrf2 is highly expressed and activated due to either the oxidative microenvironment
or genetic mutations resulting in loss of Keap1 function or gain of Nrf2 function as compared with that in normal cells [8-10]; thus, Nrf2 readily eliminates ROS from micro-environmental oxidative stressors, providing survival benefits.
Since then, her lab has piled up dozens of papers that detail how cancer cells interact with different aspects of the microenvironment
Calvi discovered that early treatment with PGE2 not only accelerated blood cell recovery, but protected the surrounding microenvironment
to stimulate production of the newly transplanted cells.
Recognition of the importance of the tumor microenvironment
in cancer evolution led to a shift from a tumor-centered view of cancer development to the concept of a complex tumor ecosystem in which cellular and molecular components are as influential as cancer cells themselves for cancer evolution and metastatic dissemination.
This discovery suggests that finding a way to block this treatment response in the tumor microenvironment
may improve the effectiveness of therapy.
The transmission of exhaled small particles from one person to another in an indoor environment can take place both directly (in the microenvironment
around the persons) and via the room air distribution.
of Florida, Shands Cancer Center) brings together 18 chapters that overview the biological and clinical relevance of the tumor microenvironment
to cancer management and fundamental areas like hypoxia, angiogenesis, stroma, and tumor cell interactions, in addition to approaches to studying the microenvironment
While the commonly held view is that changes in tumor microenvironments
are "softwired," meaning epigenetic in nature and often reversible, this work takes the view that much of the tumor microenvironment
and tumor progression is genetically controlled, or "hardwired.