microdialysis


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mi·cro·di·al·y·sis

(mī'krō-dī-al'i-sis),
A method of studying extracellular fluid composition and response to exogenous agents, using a tiny tubular probe with a dialysis membrane and fluid flow rates of 1-3 mcL/minute, inserted into tissues.

mi·cro·di·al·y·sis

(mī'krō-dī-al'i-sis)
A method of studying extracellular fluid composition and response to exogenous agents, utilizing a tiny tubular probe with a dialysis membrane and fluid flow rates of 1-3 mcL/min, inserted into tissues.

mi·cro·di·al·y·sis

(mī'krō-dī-al'i-sis)
Method of studying extracellular fluid composition and response to exogenous agents.

microdialysis,

n a technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.
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Assessment of cholinergic function in these mice by in vivo microdialysis and electrophysiological recording at the neuromuscular junction indicated a 40-50% decrease in the release of ACh (22).
Social defeat stress selectively alters mesocorticolimbic dopamine release: An in vivo microdialysis study.
To measure fat breakdown, the researchers used a technique called microdialysis to look for a marker (glycerol) left behind when stored fat is broken down for eventual production of energy.
They describe evoked potentials and electroencephalography; radiological techniques; techniques for cerebral blood flow, such as neurosonology, laser Doppler and thermal diffusion flowmetry, jugular bulb oximetry, and near infrared spectroscopy; monitoring techniques for intracranial pressure, brain oxygen, cerebral microdialysis, and brain temperature; and device development, engineering, simulation, telemedicine, robotics, information processing, data acquisition and storage, medical informatics and multimodality monitoring, noninvasive brain monitoring, and future developments.
Notes of activities were made throughout the study every 15 minutes in synchrony with a 15-minute microdialysis sample collection by a researcher in the patients' rooms.
Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis.
The neurotensin drug PD149163 was tested in rats using the conditioned avoidance response task, a model predictive of positive symptom efficacy, the inclined grip task, a model used to assess catalepsy, and microdialysis, which was used to assess dopamine release in the prefrontal cortex.
The study employed 'in vivo' microdialysis to monitor pharmacodynamic and pharmacokinetic properties of the compound VAS203.
With the use of tissue microdialysis, elevated levels of lactate, glycerol and an increased L:P ratio have been identified during CPB in myocardial and non-myocardial tissue (29-31); these are all indices of tissue ischaemia suggesting a type A mechanism underlying IHL.
On the other hand, since glutamate (Glu) and [gamma]-aminobutyric acid (GABA) play the dominant regulating effect on STN activity, changes of Glu and GABA levels in STN extracellular fluid were observed by a microdialysis study as well.
Specifically, sucrose during the first hour of daily access observed over 21 days increased extracellular DA to 130% of baseline as measured in the NAc shell by microdialysis (Avena, Rada & Hoebel 2009; Rada, Avena & Hoebel 2005).
Using microdialysis, it is currently possible to measure local exposure at the infection site in both animals and humans.