microarray


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Related to microarray: Microarray analysis, Protein microarray

microarray

(mī′krō-ə-rā′)

microarray

An array of hundreds or thousands of spots containing specific oligonucleotides, cDNAs, proteins, peptides or other small molecules chemically attached to a substrate and organised in a grid on a glass or plastic slide, silicon chip, fibre-optic array or filter membrane. The microarray is bathed with probes to analyse gene expression by hybridisation, and it is used to detect changes in gene expression by comparing radioactively or chemically labelled cDNA prepared from the total mRNA of an experimental sample to that of a control sample. The relative intensity of the signal corresponding to each spot in the microarray reveals whether the expression of a particular gene is increased, decreased or unchanged.

microarray

A collection on a chip of thousands of biological probes such as DNA single-strand sequences, protein-detecting molecules, or any other biologically-identifying material, that can be used to survey a specimen for the presence of a target gene or substance. Binding to the target substance can be made to cause fluorescence to occur at the unique spot or spots on the array and the chip can then be read by a scanner and the result displayed on a computer monitor. See also DNA MICROARRAYS.

microarray

see DNA MICROARRAY.

microarray (mīˈ·krō··rāˑ),

n a method of evaluating a large number of DNA changes on a slide which has RNA fragments attached.
References in periodicals archive ?
today announced updates to its SurePrint miRNA Microarrays to include targets from the latest public miRNA miRBase database.
Next-generation EG Microarray 12chamber can provide gene expression analysis of 12 different samples with a single chip.
In this research, microarray data were compared to those from traditional toxicology tests, which both aided in interpretation of the microarray data and led to the development of new knowledge and understanding about the toxicity of this commonly used drug.
This book is well written, but it will not be easily accessible to a general audience, particularly to laboratorians in a medical laboratory setting or to clinicians working with basic scientists on microarray projects; it does not answer the need for a simple textbook usable by researchers with only basic statistical and mathematics knowledge.
The new microarray was designed using Magnaporthe gene sequence and annotation information developed by North Carolina State University (NCSU) in collaboration with MIT's Whitehead Institute.
The key unifying principle of all microarray experiments is that labeled nucleic acid molecules in solution hybridize, with high sensitivity and specificity, to complementary sequences immobilized on a solid substrate, thus facilitating parallel quantitative measurement of many different sequences in a complex mixture (20,21).
The first commercially available microarray for the GenoSensor System, called the AmpliOnc(trademark) I, simultaneously detects abnormal increases in gene copy number from 58 different genes.
At a minimum, the journals should require valid accession numbers for microarray data as a requirement for publication, and these accession numbers should be included in the text of the manuscript to allow members of the community to find and access the underlying data.
Its major theme is providing practical information (some in a recipe format) that illustrates how to perform DNA microarray analyses.
Figure 1-3 : Growth in the United States Market for Protein Microarray Products: 2007 - 2017
With the recent delivery of a 22,000-gene zebrafish microarray developed in cooperation with TRC contractors, "we're ready to start generating a variety of different types of data using perturbations of neural tube development," he says.
Experts contend that if the use of microarray data could even double the efficiency of drug development--for example, by increasing the number of drug candidates that make it to clinical trials--the savings would be substantial.