microarray


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Related to microarray: Microarray analysis, Protein microarray

microarray

(mī′krō-ə-rā′)

microarray

An array of hundreds or thousands of spots containing specific oligonucleotides, cDNAs, proteins, peptides or other small molecules chemically attached to a substrate and organised in a grid on a glass or plastic slide, silicon chip, fibre-optic array or filter membrane. The microarray is bathed with probes to analyse gene expression by hybridisation, and it is used to detect changes in gene expression by comparing radioactively or chemically labelled cDNA prepared from the total mRNA of an experimental sample to that of a control sample. The relative intensity of the signal corresponding to each spot in the microarray reveals whether the expression of a particular gene is increased, decreased or unchanged.

microarray

A collection on a chip of thousands of biological probes such as DNA single-strand sequences, protein-detecting molecules, or any other biologically-identifying material, that can be used to survey a specimen for the presence of a target gene or substance. Binding to the target substance can be made to cause fluorescence to occur at the unique spot or spots on the array and the chip can then be read by a scanner and the result displayed on a computer monitor. See also DNA MICROARRAYS.

microarray

see DNA MICROARRAY.

microarray (mīˈ·krō··rāˑ),

n a method of evaluating a large number of DNA changes on a slide which has RNA fragments attached.
References in periodicals archive ?
Various applications of biochips and microarrays are described throughout the report.
The breadth of microarray applications is enhanced by the depth of Agilent's genomic workflow-from the 2100 Bioanalyzer and 2200 TapeStation for QC, to SureScan Scanner for data acquisition, GeneSpring for data analysis and AriaMX system for Real-Time PCR-to provide researchers a complete solution.
The market is broken down into applications of DNA microarrays, protein microarrays, emerging microarrays and lab-on-a-chip (LOAC) technologies.
EG Microarray Mouse 1200, which is loaded with 1,200 mouse genes, facilitates the process of toxicity evaluation and the analysis of chemical substances including endorine-disrupting chemicals.
For example, in microarray experiments signals take the form of fluorescence generated by the bonding of strands of mRNA to the microarray slide.
The 60-mer oligonucleotide Magnaporthe/rice microarray has more than 20,000 features, including the whole Magnaporthe grisea genome of more than 13,500 genes and more than 7,000 rice genes.
They clearly illustrate that expensive printing stations are not needed to work in the microarray field.
First described in 1995 (5), high-density DNA microarray methods have already made a marked impact on many fields, including cellular physiology (6-11), cancer biology (12-17), and pharmacology (18,19).
The GenoSensor Microarray System represents the second major technology platform that we have delivered to the marketplace.
Affymetrix scientists invented the world's first high-density microarray in 1989 and began selling the first commercial microarray in 1994.
The scientific journals should require that all primary microarray data be submitted to one of the public repositories--ArrayExpress, GEO, or CIBEX--in a format that complies with the MIAME guidelines.
Wyeth has been a pioneer in demonstrating the power of Affymetrix microarray technology in the entire drug discovery and development process," said Chip Leveille, vice president, Pharmaceutical Business Unit at Affymetrix.