mexiletine


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mexiletine

 [mek´sĭ-lĕ-tēn]
an agent used as the hydrochloride salt in treatment of ventricular arrhythmias.

mexiletine

/mex·il·e·tine/ (mek´sĭ-lĕ-tēn) an antiarrhythmic agent used as the hydrochloride salt in the treatment of ventricular arrhythmias.

mexiletine

A class-IB anti-arrhythmic which shortens the repolarisation phase by blocking sodium channels. Mexiletine also has some currency in treating refractory pain, congenital myotonias and HIV-related neuropathy.
 
Adverse effects
Heartburn, dizziness, nausea, nervousness, trembling.

mexiletine

Mexitil® Cardiology An antiarrhythmic that may have some currency in treating HIV-related neuropathy Adverse effects GI distress and dizziness

mexiletine

An antiarrhythmic drug drug used in the treatment or prevention of severe heart irregularity arising in the VENTRICLES. A brand name is Mexitil.

mexiletine

a cardiac antiarrhythmic agent with action similar to lidocaine, used in the treatment of heart disease in dogs.
References in periodicals archive ?
Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial.
Mexiletine for treatment of chronic painful diabetic neuropathy.
Addition of [Beta]-blocker or mexiletine reduced the ability to induce torsade, suggesting these medications might improve patient outcomes.
This news was especially disturbing because an earlier, company-sponsored trial with mexiletine had been terminated prematurely because of a trend toward increased mortality in the drug-treated population.
Antiarrhythmic agents - Mexiletine, procainamide, quinidine.
Contract notice: Providing three pilot batches of mexiletine hydrochloride meet the specifications requested, accompanied by a comprehensive scientific report prepared in accordance with the common technical document (ctd) in force for the pharmaceutical establishment of the ap-hp (assistance publique - hospitals of paris).
Effect of mexiletine on lipid peroxidation and early ultrastructural findings in experimental spinal cord injury.
79) Bupropion, capsaicin, citalopram, clonidine, dextromethorphan, mexiletine, paroxetine, and venlafaxine may occasionally be effective for patients with neuropathic pain who are unresponsive to first and other second-line options.
The researchers stressed that these in vitro results do not show that in vivo treatment with mexiletine would be beneficial now.
Liquid chromatographic determination of mexiletine and tocainide in human plasma with fluorescence detection after reaction with a modified o-phthalaldehyde reagent.
10) Interestingly, in this second paper the use of the oral sodium channel blocker mexiletine was not found to be effective.
other agents, such as gabapentin and other anticonvulsants, mexiletine, tramadol, and topical capsaicin also have been tried but with equivocal efficacy and safety.