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The salt or ester of mevalonic acid.
References in periodicals archive ?
The increased cholesterol substrate leads to increased archaeal growth and digoxin synthesis leading to metabolic channeling to the mevalonate pathway [34].
Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in Gram-positive cocci.
The archaeal DXP and mevalonate pathway metabolites can bind [gamma][delta] TCR and digoxin induced calcium signaling can activate NFKB producing chronic immune activation or systemic inflammatory reaction [2,33].
The archaea evolved into gram negative and gram positive bacteria with a mevalonate pathway which had an evolutionary advantage.
The polyketide biosynthetic pathway appears to be responsible for most of the classes of lichen compounds, whereas pulvinic acids are shikimate derivatives, and the abundance of di- and triterpenoids found in lichens are formed via the mevalonate pathway [12,13].
Brown, "Regulation of the Mevalonate Pathway," Nature 343, 425-430 (1990).
Squalene synthase inhibitors held the theoretical promise of having fewer side-effects than statins, as they do not deplete the mevalonate pool and so should not interfere with isoprenoid synthesis.
Both cholesterol and CoQ10 share a common biosynthetic pathway, which involves the formation of mevalonate compound with the aid of 3-hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase.
As a result, there is depletion of certain substances, eg, ubiquinone and mevalonate.
blocks synthesized by the mevalonate or methylerythritol 4-phosphate
through relatively simple adaptations of fatty acid biosynthesis, the mevalonate pathway, or through simple transformations of host precursors (5).