metyrosine

metyrosine

 [mĕ-ti´ro-sēn]
α-methyl-l-tyrosine, an inhibitor of catecholamine synthesis used to control hypertensive attacks in pheochromocytoma.

me·ty·ro·sine

(mĕ-tī'rō-sin, -sēn),
An inhibitor of tyrosine hydroxylase and therefore a powerful inhibitor of catecholamine synthesis; used for controlling the manifestations of pheochromocytoma, in preoperative preparation, or in instances where surgical resection is contraindicated or incomplete.

metyrosine

/me·ty·ro·sine/ (mĕ-ti´ro-sēn) an inhibitor of the first step in catecholamine synthesis, used to control hypertensive attacks in pheochromocytoma.

metyrosine

[mətir′əsēn]
an inhibitor of tyrosine hydroxylase, the rate-limiting enzyme for catecholamine synthesis.
indications It is prescribed in the treatment of pheochromocytoma before surgery and may be used for long-term therapy if surgery is contraindicated.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are extrapyramidal reactions, including tremor and drooling. Sedation is common, and diarrhea and anxiety may occur.

metirosine, metyrosine

l-tyrosine, an inhibitor of catecholamine synthesis used in the treatment of pheochromocytoma.
Mentioned in ?
References in periodicals archive ?
Key Words: metyrosine, myocardial infarction, pheochromocytoma
The dose was reduced and he was started on a low dose of metyrosine as a part of his preoperative treatment, the dosage of which was gradually increased to 4 g per day with no side effects.
After 10 days of phenoxybenzamine and metyrosine, the patient was taken for combined coronary artery bypass grafting (CABG) and adrenalectomy.
Combined use of alpha blockers and metyrosine therefore results in improved hemodynamic control, less blood loss, and less need for the intraoperative use of vasopressors and phentolamine, as evident in Figure 2.
decongestants) Amphetamines, buspirone, and most psychoactive agents Sotalol Methyldopa Withdrawal from clonide hydrochloride and other drugs Ethanol Benzodiazepines Decrease the values Metyrosine Methylglucaminea (a) A component of iodinated contrast media that may cause metanephrine values to be falsely normal for as long as 72 h when measured with Pisano's spectrophotometric method.