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metyrosine

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metyrosine /me·ty·ro·sine/ (mĕ-ti´ro-sēn) an inhibitor of the first step in catecholamine synthesis, used to control hypertensive attacks in pheochromocytoma.
metyrosine
[mətir′əsēn]
an inhibitor of tyrosine hydroxylase, the rate-limiting enzyme for catecholamine synthesis.
indications It is prescribed in the treatment of pheochromocytoma before surgery and may be used for long-term therapy if surgery is contraindicated.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are extrapyramidal reactions, including tremor and drooling. Sedation is common, and diarrhea and anxiety may occur.

metyrosine [mĕ-ti´ro-sēn]
α-methyl-l-tyrosine, an inhibitor of catecholamine synthesis used to control hypertensive attacks in pheochromocytoma.

metirosine, metyrosine
l-tyrosine, an inhibitor of catecholamine synthesis used in the treatment of pheochromocytoma.


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The dose was reduced and he was started on a low dose of metyrosine as a part of his preoperative treatment, the dosage of which was gradually increased to 4 g per day with no side effects.
 
 
 
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