metyrapone /me·tyr·a·pone/ (mĕ-tēr´ah-pōn) a synthetic compound that selectively inhibits an enzyme responsible for the biosynthesis of corticosteroids; it is used as a diagnostic aid for determination of hypothalamicopituitary-adrenocortical reserve.
metyrapone
metyrapone
me·tyr·a·pone (m -tîr -p n )n. An inhibitor of the hydroxylation of adrenocortical steroids administered as a diagnostic aid in determining pituitary gland function. |
metyrapone
[metir′əpōn]
a diagnostic test drug.
indications It is used to test hypothalamic and pituitary function.
contraindications Adrenocortical insufficiency or hypersensitivity prohibits its use.
adverse effects Among the most serious adverse effects are nausea, dizziness, and allergic rash.
metyrapone
a compound that selectively inhibits adrenocortical 11β-dehydroxylase and the synthesis of cortisol.
metyrapone test
blood levels of cortisol and 11-desoxycortisol are measured, before and after administration of metapyrone. In pituitary dependent hyperadrenocorticism, there is a decrease in cortisol and increase in 11-desoxycortisol; both values decrease if there is an adrenal tumor.
metyrapone
A diagnostic tool for evaluating the hypothalamus-pituitary-adrenal 'axis', especially, abnormal pituitary activity
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