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Successful medical treatment using metyrapone or ketoconazol has been reported during pregnancy.
have been examining the link between stress and addiction as they study whether a combination of the benzodiazepine oxazepam and the Cortisol synthesis inhibitor metyrapone could become the breakthrough drug for cocaine dependence.
In the management of Cushing syndrome, cortisol concentrations are used to help guide the appropriate dosing of metyrapone, a potent 11[beta]-hydroxylase inhibitor (6).
Pioneering research by mood disorder specialists at Newcastle University has questioned the effectiveness of metyrapone, a drug suggested to treat depression.
By increasing the plasma ACTH concentration by administration of ACTH or metyrapone, an inhibitor for glucocorticoid biosynthesis, the rhythm of cell replication was found to shift accordingly.
Central serotonergic responses and behavioral adaptation to repeated immobilization: the effect of the corticosterone synthesis inhibitor metyrapone.
Cushing's syndrome during pregnancy secondary to adrenal adenoma: metyrapone treatment and laparoscopic adrenalectomy.
There are various medications, such as ketoconazole, mitotane and metyrapone, to decrease serum cortisol for high-risk AIMAH.
110-113] Furthermore, D-cycloserine reverses fear extinction deficits caused by stress and other factors, [114,115] blocks the extinction-impairing effect of the corticosteroid synthesis inhibitor metyrapone, and enhances the extinction-facilitating effects of the synthetic glucocorticoid dexamethasone.
They receive either the drug metyrapone or a placebo, although as a "double blind" test even the researchers will not know who has been given what until the work is finished next year.
Delta sleep response to metyrapone in post-traumatic stress disorder.
Summary: TEHRAN (FNA)- Recalling painful memories while under the influence of the drug metyrapone reduces the brain's ability to re-record the negative emotions associated with them.