metyrapone


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metyrapone

 [mĕ-tēr´ah-pōn]
a synthetic compound that selectively inhibits an enzyme responsible for the biosynthesis of corticosteroids; it is used as a diagnostic aid in a test of pituitary reserve.

me·tyr·a·pone

(mĕ-tir'ă-pōn),
An inhibitor of adrenocortical steroid C-11 β-hydroxylation, administered orally or intravenously to determine the ability of the pituitary gland to increase its secretion of corticotropin; because 11-deoxycorticosteroids, as a consequence of metyrapone administration, only weakly inhibit pituitary corticotropin secretion, the normal pituitary gland will appreciably increase its output of this hormone.
Synonym(s): mepyrapone

metyrapone

/me·tyr·a·pone/ (mĕ-tēr´ah-pōn) a synthetic compound that selectively inhibits an enzyme responsible for the biosynthesis of corticosteroids; it is used as a diagnostic aid for determination of hypothalamicopituitary-adrenocortical reserve.

metyrapone

[metir′əpōn]
a diagnostic test drug.
indications It is used to test hypothalamic and pituitary function.
contraindications Adrenocortical insufficiency or hypersensitivity prohibits its use.
adverse effects Among the most serious adverse effects are nausea, dizziness, and allergic rash.

metyrapone

An agent used to evaluate the hypothalamus-pituitary-adrenal axis, especially abnormal pituitary activity. Metyrapone inhibits 11-beta-hydroxylase, the final enzyme in cortisol synthesis. The inhibition results in accumulation of 11-deoxycortisol in the adrenal cortex, resulting in decreased negative feedback of ACTH synthesis by the pituitary; it therefore also results in increased ACTH and increased 11-deoxycortisol, as well as its metabolite, tetrahydrocortisol, which is measured in the urine as so-called Porter-Silber compounds.

metyrapone

A diagnostic tool for evaluating the hypothalamus-pituitary-adrenal 'axis', especially, abnormal pituitary activity

metyrapone

An ALDOSTERONE inhibitor drug used to treat aldosterone-induced OEDEMA and CUSHING'S syndrome. A brand name is Metopirone.

metyrapone

a compound that selectively inhibits adrenocortical 11β-dehydroxylase and the synthesis of cortisol.

metyrapone test
blood levels of cortisol and 11-desoxycortisol are measured, before and after administration of metapyrone. In pituitary dependent hyperadrenocorticism, there is a decrease in cortisol and increase in 11-desoxycortisol; both values decrease if there is an adrenal tumor.
References in periodicals archive ?
Successful medical treatment using metyrapone or ketoconazol has been reported during pregnancy.
have been examining the link between stress and addiction as they study whether a combination of the benzodiazepine oxazepam and the Cortisol synthesis inhibitor metyrapone could become the breakthrough drug for cocaine dependence.
In the management of Cushing syndrome, cortisol concentrations are used to help guide the appropriate dosing of metyrapone, a potent 11[beta]-hydroxylase inhibitor (6).
Pioneering research by mood disorder specialists at Newcastle University has questioned the effectiveness of metyrapone, a drug suggested to treat depression.
By increasing the plasma ACTH concentration by administration of ACTH or metyrapone, an inhibitor for glucocorticoid biosynthesis, the rhythm of cell replication was found to shift accordingly.
Central serotonergic responses and behavioral adaptation to repeated immobilization: the effect of the corticosterone synthesis inhibitor metyrapone.
Cushing's syndrome during pregnancy secondary to adrenal adenoma: metyrapone treatment and laparoscopic adrenalectomy.
There are various medications, such as ketoconazole, mitotane and metyrapone, to decrease serum cortisol for high-risk AIMAH.
110-113] Furthermore, D-cycloserine reverses fear extinction deficits caused by stress and other factors, [114,115] blocks the extinction-impairing effect of the corticosteroid synthesis inhibitor metyrapone, and enhances the extinction-facilitating effects of the synthetic glucocorticoid dexamethasone.
They receive either the drug metyrapone or a placebo, although as a "double blind" test even the researchers will not know who has been given what until the work is finished next year.
Delta sleep response to metyrapone in post-traumatic stress disorder.
Summary: TEHRAN (FNA)- Recalling painful memories while under the influence of the drug metyrapone reduces the brain's ability to re-record the negative emotions associated with them.