metrifonate


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metrifonate

 [met″rĭ-fo´nāt]
an organophosphorous compound having potent anticholinesterase activity; used topically against ectoparasites and internally as an anthelmintic, especially effective against Schistosoma haematobium.

tri·chlor·fon

(trī-klōr'fon),
An organophosphorus compound effective against immature and mature stages of Schistosoma haematobium, but ineffective against other species of Schistosoma in humans.
Synonym(s): metrifonate

metrifonate

An organophosphate that is an irreversible inhibitor of acetylcholinesterase. Metrifonate had some currency for treating Schistosoma haematobium schistosomiasis, but proved less effective than praziquantel and is thus no longer used for this indication. It was being developed for Alzheimer's dementia, but was withdrawn due to adverse effects (respiratory paralysis and defects in neuromuscular transmission).

metrifonate

Neurology A cholinesterase inhibitor which is anthelmintic and used to manage dementia. See Alzheimer's disease.

metrifonate

An organophosphorus CHOLINESTERASE inhibitor drug used to kill the worms in SCHISTOSOMIASIS, especially Schistosoma haematobium.

metrifonate

an organophosphorus insecticide. See trichlorfon.
References in periodicals archive ?
Effects of praziquantel, miclosamide, levamisole hydrochloride and metrifonate on Monogenea (Gyrodactylus aculeati, Diplozoon paradoxum).
The ratio of inhibited, aged, and uninhibited forms of dimethyl phosphorylated AChE was delineated by their MS molecular weight signatures with tissue from a single mouse treated with sublethal doses of metrifonate (a DMOP inhibitor).
Stephenson LS, Kinoti SN, Latham MC, Kurz KM and J Kyobe Single dose metrifonate or praziquantel treatment in Kenyan children.
mansoni infection (contraindicated in pregnancy) and metrifonate as an alternative for S.
haematobium-infected children were randomly assigned to groups for treatment with either praziquantel (Biltricide, Bayer, Leverkusen, Germany), 40 mg/kg once a year, or metrifonate (Bilarcil, Bayer), 10 mg/kg three times a year.
In fact a related compound, metrifonate, is a potential treatment but tests on it were halted after patients suffered "muscle weakness and breathing difficulties".
The drug, Metrifonate, doesn't stop the brain cells from continuing to die, but it does make the ones that are remaining work twice as hard.
GOOD news for carers of people with Alzheimer's disease - metrifonate, which started life years ago as a treatment for tropical liver fluke disease, has shown excellent results in early Alzheimer's.
Metrifonate, which has been used to treat tropical infections, is set to revolutionise dementia therapy, while Exelon is designed specifically for Alzheimer's.
and anticholinesterases, such as donepezil, metrifonate, rivastigmine, etc.
Bayer's central nervous system research includes the development of metrifonate, a cholineasterase inhibitor for the treatment of Alzheimer's disease.
Food and Drug Administration (FDA) for metrifonate, a cholinesterase inhibitor, for the treatment of mild-to-moderate dementia of the Alzheimer's type.