methysergide


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methysergide

 [meth″ĭ-ser´jīd]
a potent serotonin antagonist and vasoconstrictor, used in the prophylaxis of migraine; also available as the maleate salt.

methysergide

/meth·y·ser·gide/ (-sur´jīd) a potent serotonin antagonist with direct vasoconstrictor effects, used as the maleate salt in prophylaxis of migraine and cluster headaches.

methysergide

A SEROTONIN antagonist ERGOT derivative drug used to treat resistant cases of MIGRAINE and some cases of persistent diarrhoea. A brand name is Deseril.

methysergide

a potent serotonin antagonist.
References in periodicals archive ?
An older clinical trial found that supplementation with 2 to 4 g of L-tryptophan daily was as effective at preventing migraine attacks as the ergot medication methysergide (Sicuteri 1973).
within 24 hours) of another 5-HT1 agonist, an ergotamine containing or ergot-type medication such as dihydroergotamine (DHE) or methysergide
CP-55,940, Naloxone, U-69,593, muscimol, MK801, yohimbine and methysergide were obtained from Tocris Cookson Ltd.
PH icin celecoxib (59), rofecoxib (60), asetilsalisilik asit (61), verapamil (61,62,63), acetozolamide (58) topiramate (64,65), steroidler (66) ve buyuk oksipital sinir blokajinin (67) etkili oldugunu bildiren vaka calismalari; HC icin ibuprofen (68), piroxicam (69,70), naproxen (71), rofecoxib (72), celecoxib (73) topiramate (74), gabapentin (75), methysergide, glukokortikoidler, buyuk oksipital sinir blokaji (76), melatonin (77,78), verapamil'in (79) etkili oldugunu bildiren olgular mevcut olsa da; indomethacin kadar tutarli yanit alinan baska bir ajan daha mevcut degildir.
In addition, several drugs may predispose patients to Raynaud's disease: beta-blockers, ergot alkaloids, sympathomimetics, clonidine, narcotics, cocaine, methysergide, some chemotherapeutic agents (e.
35 Finally, the fact that methysergide, a 5-HT antagonist, can prevent the effects of glucagon provides additional support for the postulation that serotonin, acting at the islet cells directly, is the factor responsible for the above phenomenon.
Arterial complications of migraine treatment with methysergide and parenteral ergotamine.
2B]-receptor agonists--a growing list of medications that now includes ergot derivatives (ergotamine, methysergide, and dihydroergotamine), dopamine agonists (pergolide and cabergoline), and amphetamine derivatives (fenfluramine and methylenedioxymethamphetamine [MDMA, or 'ecstasy'])," Dr.
methysergide maleate, which counteracts blood vessel constriction
SSRI use in the third trimester may cause newborn toxicity, and methysergide and other ergot alkaloids are contraindicated in pregnancy.
Therapies for migraine are either prophylactic, such as beta-blockers, calcium channel blockers, pizotifen and methysergide, or acute, such as ergot derivatives, analgesics, non-steroidal anti-inflammatory agents or narcotics very often associated with antiemetics (Schoenen et al.