methylmalonic acid


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methylmalonic acid

 [meth″il-mah-lon´ik]
a carboxylic acid that is a structural isomer of succinic acid; occurring in excess in the blood and other body fluids in methylmalonicacidemia.

meth·yl·ma·lon·ic ac·id

(meth'il-mă-lon'ik as'id),
2-Methylpropanedioic acid, an important intermediate in fatty acid metabolism; seen in elevated levels in cases of vitamin B12 deficiency. Note that methylmalonate is not methyl malonate, which is the dimethyl ester of malonate.
Synonym(s): isosuccinic acid

methylmalonic acid

/meth·yl·ma·lon·ic ac·id/ (-mah-lon´ik) a carboxylic acid intermediate in fatty acid metabolism.

methylmalonic acid

A dicarboxylic acid intermediate in fatty acid metabolism, and a C-methylated derivative of malonate, which is increased in vitamin B12 and/or folate deficiency.

Ref range
• Serum, MA, 80–300 nmol/L; homocysteine, 8–20 µmol/L.
• Urine, MA < 3.6 mmol/mol creatinine.

Specimen
Serum, random urine.
 
Method
GC/MS, HPLC

methylmalonic acid

Isosuccinic acid An intermediate in fatty acid metabolism, which is ↑ in vitamin B12 and/or folate deficiency

methylmalonic acid

a normal ruminant metabolite detoxified in animals receiving a diet adequate in cobalt. A high content in the urine suggests nutritional deficiency.
References in periodicals archive ?
The new study findings, presented at the annual meeting of the European Association for the Study of Diabetes, showed that metformin increased levels of serum methylmalonic acid (MMA), a specific biomarker of tissue [B.
Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate.
Vashi also presented an oral abstract session titled "The Relationship between Serum Vitamin B12, Methylmalonic Acid and Homocysteine in Advanced Cancer Patients.
Vitamin B12 supplementation decreased the mean homocysteine concentration by 54% and the methylmalonic acid level by 84%, whereas no significant changes were seen in the placebo group.
12] status in the NHANES, high plasma folate was associated with an increased prevalence of anaemia and cognitive impairment, and an increase in Hcy and methylmalonic acid (an index of [B.
In addition, urine methylmalonic acid and 2-methylcitrate concentrations within reference intervals made vitamin [B.
His team built on earlier work in which scientists elsewhere used an older technology, liquid chromatography-tandem mass spectrometry, to measure the same indicator compound, or biomarker, that Newman's group selected, namely, methylmalonic acid, or MMA.
His team built on earlier work in which scientists elsewhere used an older technology, liquid chromatography/tandem mass spectrometry, to measure the same indicator compound (biomarker) that the Newman group selected, namely, methylmalonic acid (MMA).
In addition, tandem mass spectrometry has been used to screen for other metabolites such as urine oligosaccharides,(4) sulfatide,(5) very long chain fatty acids,(6) long chain bile acids,(7) methylmalonic acid,(8) and for the investigation of porphyrias(9) and screening for patients at risk of inherited disorders of purine and pyrimidine metabolism.
Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians.
Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities Am J Clin Nutr 1999;70:904-10.