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a carboxylic acid that is a structural isomer of succinic acid; occurring in excess in the blood and other body fluids in methylmalonicacidemia.
meth·yl·ma·lon·ic ac·id(meth'il-mă-lon'ik as'id),
2-Methylpropanedioic acid, an important intermediate in fatty acid metabolism; seen in elevated levels in cases of vitamin B12 deficiency. Note that methylmalonate is not methyl malonate, which is the dimethyl ester of malonate.
Synonym(s): isosuccinic acid
methylmalonic acid/meth·yl·ma·lon·ic ac·id/ (-mah-lon´ik) a carboxylic acid intermediate in fatty acid metabolism.
methylmalonic acidA dicarboxylic acid intermediate in fatty acid metabolism, and a C-methylated derivative of malonate, which is increased in vitamin B12 and/or folate deficiency.
• Serum, MA, 80–300 nmol/L; homocysteine, 8–20 µmol/L.
• Urine, MA < 3.6 mmol/mol creatinine.
Serum, random urine.
methylmalonic acidIsosuccinic acid An intermediate in fatty acid metabolism, which is ↑ in vitamin B12 and/or folate deficiency
a normal ruminant metabolite detoxified in animals receiving a diet adequate in cobalt. A high content in the urine suggests nutritional deficiency.