transvenosus are known to contain macrozamin, a carcinogenic glycoside of methylazoxymethanol
(Nair & Van Staden, 2012), it is unclear whether this compound is the active ingredient in the remedies prepared using E.
For instance, test systems that evaluate neurite extension or synapse formation would not be expected to react to methylazoxymethanol
(MAM), an established DNT chemical (Penschuck et al.
Mutagenicity of the naturally occurring carcinogen cycasin and synthetic methylazoxymethanol
conjugates in Salmonella typhimurium.
16), (18) They are currently assessing arsenic, the anticonvulsant valproic acid (which has been implicated in autism spectrum disorders (19)) and methylazoxymethanol
(which is known to affect neural functioning in animals (20)) along with some other pesticides.
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol
Lack of promotive effect of quercetin on methylazoxymethanol
acetate carcinogenesis in rats.
Taxonomic significance of methylazoxymethanol
glycosides in the cycads.
All cycads, however, contain a closely related series of glycosides, with the nitrogen-containing methylazoxymethanol
(MAM) being the main toxic element (Beaton 1982:54).
As reported in this month's issue, a research group exposed cultures of immature neurons known as granule cells and the more developed and more abundant astrocytes to sublethal doses of two well-characterized alkylating genotoxicants: methylazoxymethanol
(MAM), a highly toxic compound synthesized from the poison found in plants called cycads, and nitrogen mustard (HN2), a chemotherapeutic agent.
granule cells) after treatment with two distinct alkylating agents, methylazoxymethanol
(MAM) and nitrogen mustard (HN2).
By exposing rats prenatally to a known developmental neurotoxicant, methylazoxymethanol
acetate (MAM), they blunted the increase in visual cortical thickness produced by being raised in an enriched environment.
Pregnant Long-Evans hooded rats received a single injection of either saline vehicle or 1, 5, 10, or 25 mg/kg of the well-characterized developmental neurotoxicant methylazoxymethanol
acetate (MAM) on the 16th or 17th day of gestation.