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methylases

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methylases
host cell enzymes that introduce methyl groups into bases of DNA. In prokaryotic cells two methyl groups are introduced into the palindromic sequences by the restriction endonucleases that recognize the palindrome; when methylated, the restriction enzyme does not cut the DNA so that methylation protects host cell DNA from cleavage.


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Five types of plasmid-mediated 16S rRNA methylases (ArmA, RmtA, RmtB, RmtC, and RmtD) have so far been identified in east Asia, Europe, and South America (1-7).
The activity of endogenous methylases in human placenta increased steadily with weeks of gestation, suggesting that increased formation of methyltransferases might occur during pregnancy (Paik et al.
24,25) Secondly, high-level macrolide resistance may result from modification of the drug target (ribosomal binding site) via erm(B) genes that encode 23S rRNA methylases, and lead to cross-resistance to the ML[S.
 
 
 
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