methsuximide

methsuximide

 [meth-suk´sĭ-mīd]
an anticonvulsant used in the treatment of petit mal epilepsy; administered orally.

methsuximide

/meth·sux·i·mide/ (meth-suk´sĭ-mīd) an anticonvulsant used in the treatment of seizures in absence epilepsy.

methsuximide

[methsuk′simīd]
an anticonvulsant.
indication It is prescribed in the treatment of refractory absence seizures.
contraindications Known hypersensitivity to this drug or to any succinimide prohibits its use.
adverse effects Among the more serious adverse effects are blood dyscrasias, liver and kidney damage, and systemic lupus erythematosus.

methsuximide

An antiepileptic used for absence seizures/petit mal epilepsy.

Adverse effects
Confusion, dizziness, drowsiness, headache, stomach ache, incoordination, anorexia, weight loss, nausea, vomiting, constipation, diarrhoea, insomnia.

methsuximide

Celontin® Neurology An antiepileptic used for absence seizures/petit mal epilepsy. See Therapeutic drug monitoring.

methsuximide

(methsuk´simīd),
n brand name: Celontin;
drug class: anticonvulsant;
action: inhibits spike wave formation in absence seizures (petit mal); decreases amplitude, frequency, duration, spread of discharge in minor motor seizures;
use: refractory absence seizures (petit mal).
References in periodicals archive ?
In contrast, first-generation AEDs that do not appear to be associated with a significant risk of birth defects include the benzodiazepines (clonazepam [Klonopin], clorazepate [Tranxene], diazepam [Valium], and lorazepam [Ativan]) and succinimides (ethosuximide [Zarontin] and methsuximide [Celontin]).
Other drugs assayed at therapeutic concentrations that had no interference included carbamazepine and its epoxide and hydroxy metabolites, oxcarbazepine and it monohydroxylated metabolite, zonisamide, levetiracetam, phenytoin and its metabolites, felbamate, lamotrigine, clonazepam, phenobarbital, primidone, acetaminophen, salicylate, ibuprofen, amitriptyline, nortriptyline, desipramine, doxepin and nordoxepin, imipramine, valproic acid, topiramate, mephenytoin and Nirvanol, amiodarone and desethylamiodarone, methsuximide and normethsuximide, ethotoin, clozapine, and sertraline.
Classification and Pharmacologic Management of Seizures Seizure First Line Agents New/Alternative Agents Simple Partial phenytoin primidone carbamazepine phenobarbital valproic acid gabapentin lamotrigine felbamate topiramate ethotoin mephenytoin Complex partial phenytoin primidone carbamazepine valproic acid phenobarbital mephobarbital gabapentin lamotrigine felbamate topiramate amobarbital Absence clonazepam methsuximide ethosuximide phensuximide valproic acid lamotrigine trimethadione Myoclonic valproic acid clonazepam Tonic Clonic phenytoin/fosphenytoin phenobarbital carbamazepine primidone valproic acid topiramate Stares epilepticus phenytoin/fosphenytoin diazepam lorazepam phenobarbital diazepam secobarbital pentobarbital
8 mEq/I Lorazepam (a) 5 mg/L Methsuximide (a) 5 mg/L Oxazepama 5 mg/L Phenobarbital 53 mg/L Phenytoin 30 mg/L Primidone 20 mg/L Procainamide 15 mg/L Progesterone 18 [micro]g/L Prolactin 80 [micro]g/L Prostate-specific antigen (PSA) 38 [micro]g/L Prostattc acid phosphatase (PAP) 53 [micro]g/L Quinidine 6 mg/L Salicylate 570 mg/L Testosterone 9 [micro]g/L Theophylline 26 mg/L Thyroid uptake/[T.