methoxsalen


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methoxsalen

 [mĕ-thok´sah-len]
an acrylic acid compound that induces melanin production on exposure of the skin to ultraviolet radiation; used orally and topically in the treatment of idiopathic vitiligo, mycosis fungoides, and psoriasis.

methoxsalen

/me·thox·sa·len/ (mĕ-thok´sah-len) a psoralen that induces melanin production on exposure of the skin to ultraviolet light; used in the treatment of idiopathic vitiligo, mycosis fungoides, and psoriasis.

methoxsalen

[methok′sələn]
a pigmentation agent. Also called 8-MOP.
indications It is used topically for unresponsive psoriasis and enhancement of pigmentation or for repigmentation in vitiligo and is administered orally before longwave ultraviolet irradiation of severe recalcitrant psoriasis.
contraindications Liver impairment, cataracts, age <12 yrs, any disease or concomitant use of a drug that may cause photosensitization, squamous cell carcinoma, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the most serious adverse reactions are central nervous system effects and burns. Gastrointestinal discomfort and allergic reactions also may occur.

methoxsalen

A photosensitising psoralen that is given systemically or topically before the skin is exposed to UV light, as part of treatment for psoriasis, eczema, vitiligo and some cases of cutaneous lymphoma.

methoxsalen

Oxsoralen® Dermatology A photosensitizing psoralen, given systemically or topically, after which the skin is exposed to UV light. See Psoriasis, PUVA.
References in periodicals archive ?
Similarly, methoxsalen, the main component of the aqueous extract of Poncirus trifoliata, inhibited AChE activity reducing memory loss and learning problems associated with a neurotoxicity in vivo model induced with trimethyltin [16].
Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation.
Treatment of vitiligo with oral methoxsalen and UVA.
Photochemotherapy of psoriasis with oral methoxsalen and long wave ultraviolet light.
Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis.
PUVA treatment in lichen planus: comparison of oral and external methoxsalen regimens.
M2 EQUITYBITES-February 16, 2012-Valeant Pharmaceuticals International Inc awarded FDA approval of additional manufacturer of methoxsalen for psoriasis(C)2012 M2 COMMUNICATIONS http://www.
Skin pigmentation as a predictor of minimal phototoxic dose after oral methoxsalen.
Methoxsalen (8-MOP) is a molecule found in the plant Ammi majus, which remains biologically inert unless exposed to ultraviolet radiation (4).
Por eso algunos estudios muestran que algunos inhibidores de la CYP2A6, como el methoxsalen y la tranilcipromina, suministrados en combinacion con nicotina oral, incrementan los niveles de nicotina en plasma, y son responsables de reducciones significativas de los niveles de monoxido de carbono en sangre, medidos luego de inhalar humo de cigarrillo, mostrando ademas una disminucion en el numero de cigarrillos consumidos por dia, cuando se comparan con el suministro de placebos o de nicotina oral (73).
Stern RS, Nichols KT, Vakeva LH: Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen)and ultraviolet A radiation (PUVA).