methoxamine


Also found in: Wikipedia.

methoxamine

 [mĕ-thok´sah-mēn]
a sympathomimetic amine used as a vasopressor in the treatment of acute hypotensive states, particularly to maintain blood pressure during anesthesia, and also to treat paroxysmal supraventricular tachycardia; administered intramuscularly or intravenously.

methoxamine

/me·thox·amine/ (mĕ-thok´sah-mēn) an agr;1-adrenergic agonist, used as the hydrochloride salt as a vasopressor.

methoxamine

Cardiology A vasopressor used for hypotension and PAT; it improves performance in left ventricular dysfunction, which may be linked to exercise-induced vasodilation of airway vessels

methoxamine

An alpha-adrenergic agonist drug that constricts arteries and is sometimes used in emergency to raise falling or dangerously low blood pressure. A brand name is Vasoxine.

methoxamine

a sympathomimetic amine used as the hydrochloride for its vasopressor effects.
References in periodicals archive ?
After 10 weeks, plasma triglyceride and 15-F2t-isoprostane, and insulin sensitivity were measured, and after 12 weeks, pressor response to methoxamine (15-60 microg/kg min) was assessed.
These include (29): endothelium-derived contracting factors such as endothelin, prostanoids such as thromboxane A2 and prostaglandin F2[alpha], circulating sympathomimetics ([alpha]-adrenoceptor agonists) such as norepinephrine and synthetic [alpha]l-adrenoceptor agonists like methoxamine or phenylephrine, platelet-derived substances such as 5-hydroxytryptamine and thromboxane A2, mast cells- or basophils-derived substances like histamine, muscarinic receptor agonists such as acetylcholine, renin-angiotensin system related substances such as angiotensin II and depolarizing potassium ions.
Examples of these agents used off-label are the nonsubtype-selective agonists ephedrine, pseudoephedrine, norephedrine (synonymous with phenylpropanolamine or PPA), and norfenefrine, as well as the subtype-selective [alpha]1-adrenergic receptor agonists midodrine and methoxamine.
Effect of methoxamine on maximum urethral pressure in women with genuine stress incontinence: a placebo-controlled, double-blind crossover study.
Use of methoxamine in the resuscitation of epinephrine-resistant electromagnetic dissociation.
In patients with chronic PHT, phenylephrine, methoxamine (130) and noradrenaline all increase the MAP and right coronary blood flow.
In summary, noradrenaline is superior to methoxamine and phenylephrine for the treatment of RV dysfunction due to PHT, while vasopressin should be considered for refractory cases.