Gardiner, "Pressor sensitivities to vasopressin, angiotensin II, or methoxamine
in diabetic rats," The American Journal of Physiology--Regulatory Integrative and Comparative Physiology, vol.
Role of the peripheral vasculature in changes in venous return caused by isoproterenol, norepinephrine, and methoxamine
in anesthetized dogs.
Effects of equipotent ephedrine, metaraminol, mephentermine, and methoxamine
on uterine blood flow in the pregnant ewe.
After 10 weeks, plasma triglyceride and 15-F2t-isoprostane, and insulin sensitivity were measured, and after 12 weeks, pressor response to methoxamine
(15-60 microg/kg min) was assessed.
These include (29): endothelium-derived contracting factors such as endothelin, prostanoids such as thromboxane A2 and prostaglandin F2[alpha], circulating sympathomimetics ([alpha]-adrenoceptor agonists) such as norepinephrine and synthetic [alpha]l-adrenoceptor agonists like methoxamine
or phenylephrine, platelet-derived substances such as 5-hydroxytryptamine and thromboxane A2, mast cells- or basophils-derived substances like histamine, muscarinic receptor agonists such as acetylcholine, renin-angiotensin system related substances such as angiotensin II and depolarizing potassium ions.
Drugs: The following agents were used: Acetylcholine chloride (Merck), Phentolamine methanesulfonate (CIJ3A Geigy), methoxamine hydrochloride (Burroughs Wellcome Co.
Pharmacological antagonist studies: Atropine, propranolol and phentolamine that blocked the effects of acetylcholine, isoproterenol and methoxamine respectively, did not affect the hypotensive effect of the extract.
The various vasopressors used are Ephedrine, Phenylephrine, Mephentermine, Metaraminol, Methoxamine
, Dopamine, Dobutamine and Adrenaline, though Ephedrine and Phenylephrine are the most commonly used.
Use of methoxamine
in the resuscitation of epinephrine-resistant electromagnetic dissociation.
In patients with chronic PHT, phenylephrine, methoxamine
(130) and noradrenaline all increase the MAP and right coronary blood flow.