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methotrexate/meth·o·trex·ate/ (-trek´sāt) a folic acid antagonist used as the base or the sodium salt as an antineoplastic, antipsoriatic, and antiarthritic.
methotrexateA widely used, toxic antimetabolic agent. MTX is a potent folic acid antagonist (antifolate) and competes with dihydrofolate (the natural substrate) for binding sites on dihydrofolate reductase (DHFR), blocking production of tetrahydrofolate; folate is the vitamin co-factor in methyl group transport for purine and thymidilic acid synthesis and DNA synthesis.
Nausea, vomiting, anorexia, stomatitis, CNS changes, hypersensitivity, liver damage, ocular irritation, dose-limiting myelotoxicity may appear 4–7 days after beginning therapy, nephrotoxicity (crystallisation within renal tubules).
Transient increase of LFTs.
May be used to manage tubal pregnancy; evokes resorption or tubal abortion by an unknown mechanism; failure of MTX is increased if hCG levels are increased.
Medspeak-UK: pronounced MEE tho trex ate
Medspeak-US: pronounced MEH tho trex ate
A widely used chemotherapeutic, which may be used alone to cure certain malignancies (e.g., choriocarcinoma) or with other agents for lymphoproliferations (ALL; ANLL; Hodgkin lymphoma; non-Hodgkin’s, Burkitt’s and histiocytic lymphomas; mycosis fungoides; myeloma; head and neck, ovarian and small-cell carcinomas; osteosarcoma; medulloblastoma) and nonmalignant conditions (e.g., recalcitrant psoriasis, rheumatoid arthritis, inflammatory bowel disease). Combined with cyclosporine and prednisone, MTX reduces the incidence of acute GVHD from 23% to 9%, without affecting disease-free survival.
methotrexateFolex® PFS, Rheumatrex® Oncology A widely used but toxic antimetabolic chemotherapeutic which may be used alone to treat certain malignancies–eg, choriocarcinoma, and with other agents for lymphoproliferations–ALL, ANLL, Hodgkin's disease, non-Hodgkin's, Burkitt's and histiocytic lymphomas, mycosis fungoides, myeloma, head & neck, ovarian and small cell carcinomas, osteosarcoma, medulloblastoma; nonmalignant conditions–eg, recalcitrant psoriasis, rheumatoid arthritis; combined with cyclosporine and prednisone, MTX ↓ the incidence of acute GVHD from 23% to 9%, without affecting disease-free survival; MTX is a potent folic acid antagonist–antifolate and competes with dihydrofolate—the natural substrate, for binding sites on dihydrofolate reductase–DHFR, blocking production of tetrahydrofolate–folate is the vitamin co-factor in methyl group transport for purine and thymidilic acid synthesis and DNA synthesis. See Leucovorin rescue, MDR gene Toxicity N&V, anorexia, stomatitis, CNS changes, hypersensitivity, liver damage, ocular irritation, dose-limiting myelotoxicity may appear 4-7 days after beginning therapy, nephrotoxicity–crystallization within renal tubules Lab Transient ↑of LFTs.
methotrexateAn ANTIMETABOLITE and IMMUNOSUPPRESSIVE drug used to treat cancer and help in the treatment of RHEUMATOID ARTHRITIS. It acts by interfering with the metabolism of FOLIC ACID. The drug is on the WHO official list. A brand name is Maxtrex.
methotrexateantimetabolite agent that inhibits cell proliferation; used to treat acute lymphoblastic lymphoma, non-Hodgkin's lymphoma, psoriasis and rheumatoid arthritis; administered in conjunction with folic acid, to prevent myelosuppression and anaemia
Patient discussion about methotrexate
Q. Is methotrexate available in the United States as a treatment for fibromyalgia? Last year I was diagnosed as fibromyalgia. I feel a lot of fatigue and stiffness. I came upon a website from where I read that rheumatoid arthritis causes those same symptoms and can be treated with methotrexate. After reading that, I purchased a half year supply of the drug over the counter in Mexico. It eliminated all of my symptoms. A month after my supply ran out, all the symptoms returned. Is methotrexate available in the United States as a treatment for fibromyalgia?