methionine aminopeptidase-2

methionine aminopeptidase-2

A cobalt- and magnesium-binding cytoplasmic methionyl aminopeptidase encoded by METAP2 on chromosome 12q22, which plays a key role in regulating post-translational processing and protein synthesis, by hydrolysing N-terminal methionine from newly synthesized proteins. It is a molecular target for angiogenesis inhibitors and thus has therapeutic potential in tumour progression, diabetic retinopathy, rheumatoid arthritis, and other conditions characterised by angiogenesis.
References in periodicals archive ?
PPI-2458 is a novel, proprietary, orally available small molecule that specifically targets methionine aminopeptidase-2 (MetAP-2).
PPI-2458 is a novel, proprietary, orally available small molecule that specifically targets the enzyme, methionine aminopeptidase-2 (MetAP-2).
E[acute accent]PPI-2458 is a novel, proprietary small molecule belonging to the fumagillin class of compounds that specifically targets the methionine aminopeptidase-2 (MetAP-2) enzyme.
The Company's presentation, entitled "Targeted Cancer Therapies: Inhibitors of Methionine Aminopeptidase-2," will be delivered by William Westlin, Ph.
The Company's presentation, entitled "Inhibitors of Methionine Aminopeptidase-2 (MetAP-2) in the Treatment of Non-Hodgkin's Lymphoma," was delivered by William Westlin, Ph.