methapyrilene


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methapyrilene

An ethylenediamine antihistamine and anticholinergic once used in over-the-counter cold medicine and sleeping aids. It was found to be carcinogenic in rats and removed from the market in 1979.
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KEY WORDS: DNA microarray, gene expression, hepatotoxicity, liver, methapyrilene, toxicogenomics.
studies examined hepatic gene expression in rats treated from 1 to 7 days with methapyrilene at doses of 10 mg/kg and 100 mg/kg, whereas the Beekman et al.
Thus, to facilitate the identification of toxicity-related genes, we compared gene changes in a nontarget tissue for toxicity--the kidney--with those of the target organ of methapyrilene toxicity--the liver--in addition to analyzing gene expression changes across dose level and number of doses.
Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene.
Histopathological and clinical chemistry observations on the methapyrilene-exposed animals were consistent with expected toxicities associated with methapyrilene treatment.
Results of gene expression analysis on the NIEHS cDNA platform of RNA from livers of rats treated with the high dose of methapyrilene for 7 days at both of the in vivo study sites showed good agreement.
Methapyrilene Company Microarray platform Boehringer-Ingelheim Affymetrix Pharmaceuticals, Inc.
Number of genes regulated by methapyrilene across the different companies in the pooled and individual samples at the high dose.
A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay.
Carcinogenesis by nonmutagenic chemicals: early response of rat liver cells induced by methapyrilene.
Pooled RNA samples were obtained from the methapyrilene study as described in Waring et al.
This 74-bp sequence is completely homologous with the alpha-2 microglobulin accession number X14552 and J00738 sequences, qRT-PCR of an amplicon overlapping this 74-bp sequence, as well as for the alpha-2 microglobulin sequences X14552 and J00738, showed a substantial reduction (> 100-fold) in message levels for the day 7 high-dose methapyrilene sample, whereas a similar analysis of amplicons designed for the amplification of U18419 and AL180288 showed induction levels above 5-fold (Figure 2).