Feasibility of shortened methacholine challenge
in preschool children.
tests were conducted between 1984 and 2000 using procedures adapted from Chatham et al.
Value of a negative aeroallergen skin-prick test result in the diagnosis of asthma in young adults: Correlative study methacholine challenge
Airway hyper responsiveness was documented by a positive methacholine challenge
Of the 206 subjects who had a methacholine challenge
, 16% (32) demonstrated BHR.
History and laryngoscopy ruled out asthma in half (13) of the patients mistakenly diagnosed with it; methacholine challenge
testing excluded the other half.
A positive response is indicated when there is a 15% reduction in lung function from baseline compared to a 20% fall required by a methacholine challenge
In addition, patients with vitamin D concentrations below 30 ng/mL had significantly greater airway hyperresponsiveness to methacholine challenge
than patients with adequate vitamin D concentrations.
significant bronchoprotection against methacholine challenge
The drug also gives a prolonged, dose-dependent protection against inhaled methacholine challenge
Chest examination revealed diffuse wheezing and a prolonged expiratory phase, and pulmonary function testing with a methacholine challenge
confirmed hyperreactive airways.
The primary objective of the trial was to compare the ability of NCX 1020, budesonide and placebo to relax the bronchial smooth muscle of the airways following methacholine challenge
(see note 2).