methacholine challenge

methacholine challenge

[meth′əkō′lēn]
a method of measuring airway activity by an inhalation challenge test. The patient inhales a saline aerosol as a control, followed by increasing concentrations of methacholine chloride, a cholinergic drug. The test is used to confirm the diagnosis of asthma when symptoms are not present. This is a potentially dangerous test and should be performed only by qualified personnel, with resuscitation equipment readily available.
References in periodicals archive ?
20) This prospective standardized evaluation included full PFTs, chest HRCT, methacholine challenge testing (MCT), and fiberoptic bronchoscopy with BAL.
In one small study of asthmatic patients receiving propranolol, there was no effect on methacholine challenge response, histamine responsiveness, or asthma control questionnaire results.
Steroids don't affect methacholine challenge in teens
Methacholine challenge tests were conducted between 1984 and 2000 using procedures adapted from Chatham et al.
Value of a negative aeroallergen skin-prick test result in the diagnosis of asthma in young adults: Correlative study methacholine challenge testing.
A positive response to any of the four questions on the survey has a sensitivity of 75% and a specificity of 80% for asthma symptoms on the basis of a clinical examination with immunoglobulin E testing against common allergens, spirometry, and methacholine challenge testing (MCT).
Airway hyper responsiveness was documented by a positive methacholine challenge test.
To define airway hyperresponsiveness, the study used a standard criterion: methacholine challenge cutoff of less than 8 mg/mL for causing a 20% fall in [FEV.
History and laryngoscopy ruled out asthma in half (13) of the patients mistakenly diagnosed with it; methacholine challenge testing excluded the other half.
Primary Outcome Measures: Methacholine challenge test, a variety of pulmonary function tests, subjective quality of life scores, C-reactive protein (CRP), and exhaled nitric oxide (NO)