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methacholine challenge

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methacholine challenge
[meth′əkō′lēn]
a method of measuring airway activity by an inhalation challenge test. The patient inhales a saline aerosol as a control, followed by increasing concentrations of methacholine chloride, a cholinergic drug. The test is used to confirm the diagnosis of asthma when symptoms are not present. This is a potentially dangerous test and should be performed only by qualified personnel, with resuscitation equipment readily available.


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The study design called for a 2- to 8-week run-in period, during which patients underwent pH probe monitoring and, if not contraindicated, methacholine challenge testing.
9) Methacholine challenge testing may be useful in this situation, and a normal diffusing capacity will rule out emphysema in current and ex-smokers.
We assessed airway responsiveness by methacholine challenge testing using an automatic inhalation-synchronized Mefar MB3 dosimeter jet nebulizer (Mefar SpA.
 
 
 
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