methacholine


Also found in: Dictionary, Thesaurus, Wikipedia.
Related to methacholine: Methacholine challenge test

methacholine

 [meth″ah-ko´lēn]
a cholinergic agonist, having a longer duration of action than acetylcholine and predominantly muscarinic effects; it has vasodilator and cardiac vagomimetic effects but has largely been replaced by other drugs. It is also used in bronchial challenge tests.

methacholine

[meth′äko′lēn]
a cholinergic agonist, having a longer duration of action than acetylcholine and predominantly muscarinic effects. It has vasodilator and cardiac vagomimetic effects but has largely been replaced by other drugs. It is also used in bronchial challenge tests.

methacholine

a synthetic choline ester with pharmacological effects similar to those of acetyl choline, but has little effect on alimentary tract and is little used in veterinary medicine.
References in periodicals archive ?
A prospective longitudinal study of methacholine airway responsiveness as a predictor of pulmonary-function decline: the Normative Aging Study.
Pulmonary function tests and airway responsiveness to methacholine in chronic bronchiectasis of the adult.
Two weeks later, the scientists exposed the animals' airways to albumin and the mucus-stimulating drug methacholine.
95070 INHALATION BRONCHIAL CHALLENGE TESTING: with histamine, methacholine, or similar compounds
Specific airway resistance was determined by dual chamber plethysmography and was collected at baseline and during methacholine (MCh) challenge following the final iSPERSE-enabled dry powder treatment.
3]-induced change in bronchial reactivity to methacholine and airway inflammation in humans.
32) Hyperglycemia produces a similar significant decrease in forearm blood flow change in response to the vasodilator methacholine.
ASM-024 demonstrated a highly-significant effect on FEVeu and methacholine PCeeeC pre-allergen challenge in a phase 2 study utilizing the solution for nebulization formulation.
The 1 999 ATS "Guidelines for Methacholine and Exercise Challenge Testing" suggests testing for exercise-induced bronchospasm (EIB) using a ventilatory target of 40 -60% of the subject's MVV.
Ovalbumin (OVA), Minimum Essential Medium (MEM), pyruvate, antibiotics and Methacholine (MCh) were all purchased from Sigma Chemical Co.
Saline diluent was administered initially and thereafter methacholine in doubling dosages from 0.