methacholine


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Related to methacholine: Methacholine challenge test

methacholine

 [meth″ah-ko´lēn]
a cholinergic agonist, having a longer duration of action than acetylcholine and predominantly muscarinic effects; it has vasodilator and cardiac vagomimetic effects but has largely been replaced by other drugs. It is also used in bronchial challenge tests.

methacholine

[meth′äko′lēn]
a cholinergic agonist, having a longer duration of action than acetylcholine and predominantly muscarinic effects. It has vasodilator and cardiac vagomimetic effects but has largely been replaced by other drugs. It is also used in bronchial challenge tests.

methacholine

a synthetic choline ester with pharmacological effects similar to those of acetyl choline, but has little effect on alimentary tract and is little used in veterinary medicine.
References in periodicals archive ?
The effects of tangeretin (25 and 50 mg/kg) on AHR in reaction to increasing doses of methacholine were determined in terms of RI and Cdyn in mice under mechanical ventilation.
Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation.
A double-blind, placebo-controlled RCT of 56 adolescents found that giving ICS after viral upper respiratory infection didn't change the methacholine dosing necessary to produce a 20% reduction in the forced expiratory volume in one second ([FEV.
We tested methacholine as a tracheal contraction drug.
A positive response to any of the four questions on the survey has a sensitivity of 75% and a specificity of 80% for asthma symptoms on the basis of a clinical examination with immunoglobulin E testing against common allergens, spirometry, and methacholine challenge testing (MCT).
Airway hyper responsiveness was documented by a positive methacholine challenge test.
Patients were observed by internal medicine specialist to diagnose asthma based on Global Initiative for Asthma (GINA) or 20% drop in the FEV1 on methacholine test.
Compared with placebo, all three ICS regimens reduced treatment failures (more than two exacerbations requiring oral corticosteroids) in boys, in children 611 years old, and in children with allergic forms of the disease as indicated by eczema, positive skin tests, methacholine [PC.
Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo.
Methacholine is a drug which is used to measure the sensitivity of airways by causing a transient narrowing of the airways.