In a double-blind, placebo-controlled crossover study, researchers administered the serotonin receptor antagonist metergoline to women with PMDD whose symptoms had remitted during treatment with fluoxetine and a group of healthy controls who were not receiving any medication.
Effects of metergoline on symptoms in women with premenstrual dysphoric disorder.
Furthermore, a non-selective serotonin receptor antagonist, metergoline (4), and a [alpha]-2a adrenergic receptor antagonist, BRL44408 (5), were used to evaluate the roles of the serotoninergic and adrenergic systems, respectively
Furthermore, polyethylene glycol and ethanol, which were used to dissolve metergoline and BRL44408, respectively did not produce any different effects when used as a single agent (Figure 6).
The antinociceptive effect that was induced by mirtazapine was partially antagonized by naloxone [opioidergic system contribution; (14,15)], metergoline (serotoninergic system contribution; 14), and BRL44408 [adrenergic system contribution; (14,16)] in this study.
La administracion de agonistas dopaminergicos como la bromocriptina, caber goline, quinagolide, metergoline
y lisuride inhiben la produccion de prolactina causando una disminucion del volumen celular individual y subsecuentemente inducen la reduccion tumoral; la normalizacion de los niveles de prolactina con el uso de la terapia dopaminergica ha sido reportada en un 70-90% y el decrecimiento tumoral en un 80-90%12.