Thus, for example, were a graduate student and dissertator in africology to be interested in the relation between metatropic
(requiring dead organic matter for food) factors, iron smelting, and the eventual ruin of ancient Meroe in Sudan, not just for antiquarian reasons but to discern significance that is informative to contemporary humanity regarding their subspecies life, it is the resource force which would engender means whereby that work could be done empirically.
Metatropic dysplasia (metatropic-changing hypertrophic achondroplasia) was described in 1966 by Maroteaux et al.
2) In addition, the observation of an overlap between the autosomal recessive non-lethal form and the non-lethal autosomal dominant form, the rarity of sibship recurrences and the observation of vertical transmissions of metatropic dysplasia in the literature argue in favor of an autosomal dominant mode of inheritance.
Radiographic skeletal survey revealed characteristic vertebra plana (dense wafer thin), dumbbell shaped long bones, kyphosis, halberd shaped pelvis, squared calcaneus and coccygeal appendage consistent with the diagnosis of metatropic dysplasia.
5) Recent research has pointed out that mutations in TRPV4, a calcium permeable ion channel produce a phenotypic spectrum of skeletal dysplasias from the mild autosomal-dominant brachyolmia to SMDK to autosomal dominant metatropic dysplasia, suggesting that these disorders should be grouped into a new bone dysplasia family.
Understanding the clinical spectrum of metatropic dysplasia, careful patient selection and appropriate intervention has great potential for functional improvement and hence, leading an independent social life for these challenging cases.
Revisiting metatropic dysplasia: presentation of a series of 19 novel patients and review of the literature.