Following approval by the Institutional Committee on Human Research, 13 patients with EHE (8 primary to bone, 5 involving soft tissue) and 13 patients with metastatic carcinoma
to bone were retrieved from the files at the Department of Pathology University of California, San Francisco.
In a series of cases of metastatic carcinoma
reported by McNichols et al, 11% of patients had first received treatment for their primary hypemephroma more than 10 years earlier.
The sNDA seeks marketing approval for the use of Doxil(R) in the treatment of patients with metastatic carcinoma
of the ovary, who are refractory to both paclitaxel- and platinum-based chemotherapy regimens and who may be refractory to topotecan therapy.
of the skin (erysipelas carcinomatosum).
The FDA initially cleared TAXOL on December 29, 1992, for use after failure of first-line or subsequent chemotherapy for treatment of metastatic carcinoma
of the ovary, with doses administered over 24 hours every three weeks.
Epithelioid and epithelial neoplasms seen in bone are rare and include epithelioid variants of vascular lesions, osteoblastoma, osteosarcoma, chordoma, and chondroblastoma as well as adamantinoma and metastatic carcinoma
The FDA first cleared TAXOL on December 29, 1992, for use after failure of first-line or subsequent chemotherapy for the treatment of metastatic carcinoma
of the ovary.
Sixty-six pathologists (37%) gave a false neoplastic diagnosis (hepatocellular carcinoma, 21; metastatic carcinoma
not otherwise specified [NOS], 1; metastatic small cell carcinoma, 1; benign neoplasm NOS, 5; hepatocellular adenoma, 36; adenocarcinoma including primary or metastatic, 2), whereas 7 pathologists gave a false suspicious diagnosis (hepatocellular carcinoma, 3; necrotic-nondiagnostic, 1; benign neoplasm NOS, 1; inflammatory, 1; other, 1).
1) The procedure is highly selective as a method for detecting the lymph node or nodes most likely to harbor metastatic carcinoma
, Consequently, the staging of the axilla can be accomplished by this method without the morbidity of a full axillary dissection.
1) Per unit weight, the adrenal glands are involved in metastatic carcinoma
more than any other organ.
Once the presence of neoplastic cells is recognized, the differential diagnosis includes mainly epithelioid hemangioendothelioma, Kaposi sarcoma, and pseudoangiomatous variants of metastatic carcinoma
(see Table 3).
Differentiation between a primary soft tissue sarcoma and metastatic carcinoma
to muscle is important, since their treatment and prognosis are so markedly different.