metaplasia


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metaplasia

 [met″ah-pla´zhah]
the change in the type of adult cells in a tissue to a form abnormal for that tissue. adj., adj metaplas´tic.
agnogenic myeloid metaplasia the primary or idiopathic form of myeloid metaplasia, which is often accompanied by myelofibrosis; it is considered one of the myeloproliferative disorders. Called also aleukemic or nonleukemic myelosis.
myeloid metaplasia the occurrence of myeloid tissue in extramedullary sites; specifically, a syndrome characterized by splenomegaly, anemia, nucleated erythrocytes and immature granulocytes in the circulating blood, and extramedullary hematopoiesis in the liver and spleen. The primary form is called agnogenic myeloid metaplasia. The secondary or symptomatic form may be associated with various diseases, including carcinomatosis, tuberculosis, leukemia, and polycythemia vera.

met·a·pla·si·a

(met'ă-plā'zē-ă),
Abnormal transformation of an adult, fully differentiated tissue of one kind into a differentiated tissue of another kind; an acquired condition, in contrast to heteroplasia.
Synonym(s): metaplasis (2)
[G. metaplasis, transformation]

metaplasia

/meta·pla·sia/ (met″ah-pla´zhah) the change in the type of adult cells in a tissue to a form abnormal for that tissue.metaplas´tic
myeloid metaplasia  a syndrome characterized by myeloid tissue in extramedullary sites with nucleated erythrocytes and immature granulocytes in the circulating blood and extramedullary hematopoiesis in the liver and spleen, as well as anemia and splenomegaly. Both a primary form (agnogenic myeloid m.) and forms secondary to carcinoma, leukemia, leukoerythroblastosis, and tuberculosis are known.

metaplasia

(mĕt′ə-plā′zhə)
n.
1. Normal transformation of tissue from one type to another, as in the ossification of cartilage to form bone.
2. Transformation of cells from a normal to an abnormal state.

met′a·plas′tic (-plăs′tĭk) adj.

metaplasia

[met′əplā′zhə]
the reversible conversion of normal tissue cells into another, less differentiated cell type in response to chronic stress or injury. With prolonged exposure to the inducing stimulus, cancerous transformation can occur.

metaplasia

The conversion of one type of adult tissue and/or cells—most commonly epithelia—into another; e.g., squamous metaplasia, in which non-keratinised squamous epithelium replaces ciliated columnar cells in the bronchi of smokers.

Metaplasia types
• Intestinal metaplasia—occurs in the stomach, especially in stomachs that later develop adenocarcinoma. 
• Paneth cell metaplasia and enterochromaffin cell metaplasia—occur in the gallbladder, and are associated with adenocarcinoma of same.  
• Squamous metaplasia—the transformation of glandular or ciliated epithelium to stratified sqamous epithelium. In SM of the upper respiratory tract, squamous epithelium replaces ciliated columnar epithelium; this event, particularly common in smokers, feeds the controversy that this metaplasia may represent a dysplastic process with premalignant potential. Squamous metaplasia of the endocervix is not associated with malignancy. 
• Tubal metaplasia of the endometrium—i.e., replacement of the normal endometrial glands with ciliated (fallopian) tubal cells—may occur in endometrial polyps, mild adenomatous hyperplasia and in senile endometrium, but is rarely (and then only coincidentally) associated with malignancy.

met·a·pla·si·a

(met'ă-plā'zē-ă)
Abnormal transformation of an adult, fully differentiated tissue of one kind into a differentiated tissue of another kind; an acquired condition, in contrast to heteroplasia.
[G. metaplasis, transformation]

metaplasia

An abnormal change in the character or structure of a tissue as a result of changes in the constituent cells. Metaplasia often involves a change of cells to a less specialized form and may be a prelude to cancer.

metaplasia

the transformation of a tissue to another form.

metaplasia (meˈ·t·plāˑ·zhē·),

n abnormal cell growth in which cells become unlike the normal cells in the tissue of which they are a part.

met·a·pla·si·a

(met'ă-plā'zē-ă)
Abnormal transformation of an adult, fully differentiated tissue of one kind into a differentiated tissue of another kind; an acquired condition, in contrast to heteroplasia.
[G. metaplasis, transformation]

metaplasia (met´əplā´zhə),

n a change in the type of adult cells in a tissue to a form that is not normal for that tissue.

metaplasia

the change in the type of adult cells in a tissue to a form abnormal for that tissue.

Patient discussion about metaplasia

Q. what is metaplasia i had 2 surgeries in my left breast for some cyst they found metaplasia in the biopsy

A. from what i remember while reading on the subject- cells can go through different changes. one of them is metaplasia- change of form. our body is amazingly flexible, and under stress cells can change form and function. like if you have continues heartburns, cells in your esophagus will change to cells similar to the stomach and start excreting anti acid materials. finding that on a biopsy means the cells in the cyst changed function.

Q. what is fragments of endocervical glandular mucosa with inflammation and squamous metaplasia fragments of endocervical glandular mucosa

A. It means that part of the mucose on the cervix area has changes from a certain kind of mucose cells to another, and that there is a bit of an inflammation around it. This should be brought to the knowledge of a gynecologist and be monitored by him/her.

More discussions about metaplasia
References in periodicals archive ?
Chronic inflammation and squamous metaplasia were present.
Thus, in contrast to the studies from the countries with higher incidence of gastric cancer, such as Japan, we observed very low rates of the grievous precancerous changes such as atrophic gastritis and intestinal metaplasia.
Infarction and squamous metaplasia of intraductal papilloma: a benign breast lesion that may simulate carcinoma.
Immunohistochemical analysis of apocrine breast lesions: consistent overexpression of androgen receptor accompanied by the loss of oestrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ.
In addition, immunohistochemical studies and mucin profiling to estimate intestinal metaplasia mucin expressions, among other tests were also conducted.
The purpose of this study is to show the significant association of squamous metaplasia (the precursor for cervical cancer), hyperkeratosis, and parakeratosis, and as the Pap smear finding in patients with uterine prolapse, which is sparsely represented in the literature despite the high incidence of the later.
A nasal polyp with osseous metaplasia is a rare finding.
sup][1],[2] Long-term duodenogastric reflux (DGR) can cause pathological conditions such as chronic gastritis, foveolar hyperplasia, intestinal metaplasia, gastric dysplasia, gastric polyp, and gastric cancer.
GlobalData's clinical trial report, "Myeloid Metaplasia Global Clinical Trials Review, H2, 2015" provides an overview of Myeloid Metaplasia clinical trials scenario.
To increase the accuracy of endoscopic diagnosis, we carried out an additional chromoendoscopy with methylene blue staining allowing the detection of foci of intestinal metaplasia (IM) of gastric mucosa which were unrecognized by routine endoscopy.