metalloproteinase inhibitor


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.
Related to metalloproteinase inhibitor: metalloprotease inhibitor

metalloproteinase inhibitor

Any of numerous compounds that inhibit the activity of the metalloproteinase family of enzymes. These agents share the ability to suppress or eliminate the enzyme activity of the metalloproteinases. Agents identified in this group include the tetracycline antibiotics, numerous specially designed synthetic peptides and proteins, chemicals such as ethylenediaminetetra-acetic acid (EDTA), and a variety of agents used in cancer chemotherapy. Synonym: metalloprotease inhibitor
See also: inhibitor
References in periodicals archive ?
There is convincing evidence that metalloproteinases are involved in the formation of the truncated soluble form of BACE-1 in cell culture because, in the presence of metalloproteinase inhibitors, the amount of the soluble form is decreased considerably.
MultiStat is Quick-Med's proprietary family of compounds - generally called Matrix Metalloproteinase Inhibitors - that represent a new frontier in anti-aging skin care.
It is a member of a class of compounds called Matrix Metalloproteinase Inhibitors (MMPI) that modern research has shown to play key roles in skin cell biology.
matrix metalloproteinase inhibitors, multidrug resistance inhibitors, antisense oligonucleotides) have failed to fulfill their promise to date.
It is a highly successful member of a class of compounds called Matrix Metalloproteinase Inhibitors (MMPI) that modern research has shown to play key roles in skin cell biology.
vacuum therapy, new casting techniques, the use of hormones and growth factors in wound healing; there have been advances in the understanding of the biomechanics of foot problems; there are increased problems with multidrug-resistant organisms and new international guidelines have been introduced for the management of infectious disease; finally, there has been significant progress in the use of cytokines, metalloproteinase inhibitors, stem cells and gene therapy in wound healing.
s family of techniques and compounds called Matrix Metalloproteinase Inhibitors that modern research has shown to play a key role in treating numerous skin conditions.
The strategic review also concluded that further research into matrix metalloproteinase inhibitors (MMPIs) and other metalloenzyme inhibitors (MEIs) would no longer be conducted independently by British Biotech.
These approaches include angiogenesis-inhibiting agents, matrix metalloproteinase inhibitors (MMPIs), signal transduction inhibitors, antibodies to surface markers and growth factors, gene therapies, vaccines, and bioreductive agents.
Matrix metalloproteinase inhibitors (MMPIs) are being developed for various forms of cancer, arthritis (osteoarthritis and rheumatoid arthritis), periodontal diseases, and ocular diseases.
In September 1999 we established a collaboration with Schering-Plough to develop and commercialize matrix metalloproteinase inhibitors for cancer, including marimastat.
2 million) and resulted principally from the agreement with Schering-Plough to develop and commercialize matrix metalloproteinase inhibitors (MMPIs) for cancer.

Full browser ?