metalloestrogen

metalloestrogen

A class of inorganic xenoestrogens that can activate oestrogen receptor-alpha and affect gene expression.

Examples
Aluminium, antimony, barium and divalents (cadmium, chromium, cobalt, copper, lead, mercury, nickel, tin, arsenite, selenite, vanadate), which have 25–100% of the receptor activity of 17 beta-estradiol.
References in periodicals archive ?
here is increasing concern that cadmium acts as a metalloestrogen (Fechner et al.
Dose-and route-dependent hormonal activity of the metalloestrogen cadmium in the rat uterus.
KEY WORDS: cadmium, endocrine disruption, estrogen-like effects, metalloestrogens, estrogen receptors, uterus.
Recently, it was proposed that cadmium acts as a metalloestrogen via interactions with estrogen receptor-[alpha] (ER-[alpha]), stimulating downstream estrogen-related processes (Carcia-Morales et al.
Thus, actions for cadmium as a metalloestrogen in this case are unlikely.
The researchers speculate that parental exposures to endocrine-disrupting chemicals, including metalloestrogens such as methylmercury, might be factors undermining the conception and survival of male children.
Whether avoidable environmental or other factors--such as widespread exposure to metalloestrogens or other known or suspected endocrine-disrupting materials, changes in parental age, obesity, assisted reproduction, or nutrition--may account for some of these patterns is a matter that merits serious concern.
One possibility we believe merits evaluation is the body burden of mercury or other metalloestrogens, to which male fetuses may be more susceptible.