metachronous

me·tach·ro·nous

(mĕ-tak'rō-nŭs),
Not synchronous; multiple separate occurrences, such as multiple primary cancers developing at intervals.
[meta- + G. chronos, time]

metachronous

adjective Referring to lesions or conditions that appear at times differing from an event of interest—i.e., not synchronous.

metachronous

adjective Referring to conditions that appear at times differing from an event of interest–ie, not synchronous

metachronous

(mĕ-tăk′ră-nŭs) [″ + Gr. chronos, time]
Occurring at a different time than another similar event. The term is the antonym of synchronous. It is often used to describe two or more tumors of similar pathological type detected at different times within the body.
References in periodicals archive ?
The question posed was whether this mass could be ascribed to metastatic supraglottic carcinoma or if it was indeed a metachronous primary bronchus carcinoma, as the treatment of these two malignancies differs significantly.
20) Furthermore, although complications with adrenalectomy with RN may be minimal (except those with metachronous contralateral adrenal metastasis), the impact of adrenal insufficiency can be devastating.
IRVING, Texas, May 30, 2015 /PRNewswire/ --Caris Life Sciences today announced the presentation of data from a study in which researchers identified biomarker changes, including key driver mutations, in 89% of metachronous paired glioma tumors, indicating changes in response to therapy as the disease progresses.
3-5) To the best of our knowledge, this is the first case of the metachronous basal-cell carcinoma of the nasolabial fold and plasma cell leukemia occurring in the same DM patient over a period of time.
Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study.
Approximately one third of cases are diagnosed as synchronous, while the other two thirds are diagnosed as metachronous.
One way to determine the fate of these tumor cells in patients with cancer is analysis of the correlation between tumor cell detection in the liver and metachronous development of hepatic metastases in patients who underwent surgery of the primary tumor and were initially staged M0.
The metachronous presentation of these two entities, which to our knowledge has not been reported previously in the literature, indicates the potential association of paragangliomas with the formation of cholesterol granulomas of the petrous apex.
When H/DS is associated with an indolent B-cell leukemia/lymphoma, either metachronous or concurrent, the issue of its clonal relationship with the primary B-cell neoplasm is raised.
present at the time of diagnosis, while in two-thirds metastases are metachronous, presenting later.
Several epidemiological studies show, in some families, a possible, either syncronous or metachronous, association of other tumors (breast, brain, gastrointestinal tumors, lymphomas) with PC, thus suggesting a common genetic background.
These patients were matched retrospectively for prior treatments and tumour burden with a contemporary cohort of >500 patients who received BSC from 3 centres in Germany to identify 29 consecutive patients with at least 2 of 4 specific matching criteria (the presence of synchronous or metachronous metastases, tumour burden, increased alkaline phosphatase, and/or carcinoembryonic antigen[CEA] >200 U/mL).