metabotropic receptor


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Related to metabotropic receptor: Metabotropic glutamate receptor

me·tab·o·tro·pic re·cep·tor

a type of receptor that is linked to intracellular production of 1,2-diacylglycerol and inositol 1,4,5-trisphosphate.
[metabolism + G. tropē, turning, inclination, + -ic]

metabotropic receptor

A type of G protein-coupled membrane receptor indirectly linked to ion-channels through signal transduction, typically by G protein signalling. In contrast to ionotropic receptors—which form ion channels and when activated open those channels to ions such as Na+, K+ or Cl-, allowing their flow in or out of cells—metabotropic receptors do not form ion channels. Metabotropic receptor activation triggers intracellular events that lead to the production of second messengers, which influence ionotropic receptors and ion channel opening.
References in periodicals archive ?
Each neuron carries receptors for both excitatory and inhibitory neurotransmitters on its surface; moreover, some of the signals will be mediated through ionotropic receptors and induce fast responses whereas others will be mediated through metabotropic receptors and trigger slow responses.
AMPA, NMDA, and metabotropic receptors have been found in the vestibular nuclei.
Thirteen chapters deal with N-methyl-n-aspartate (NMDA) receptors, 8 with 2-amino-3-hydroxy-5-methyl-4-isoxazole propicnic acid (AMPA) receptors, 6 with kainate receptors, and 6 with metabotropic receptors.
It has been previously shown that the intrinsic biochemical steps of STM include the activation of glutamate NMDA, AMPA and metabotropic receptors in the CAI region of the hippocampus, and that STM is activated by AMPA, but not NMDA receptors in the entorhinal cortex (Izquierdo et al.
Binding of glutamate to metabotropic receptors involves guanosine nucleotide-binding protein (G-protein).
Among the three known classes of GABA receptors, GABAa and GABAc ionotropic receptors (ion channels), and GABAb metabotropic receptors (G protein-coupled receptors), the GABAa receptor is one of the most promising targets for a wide range of CNS-related diseases including anxiety, irritability, insomnia, and depression (Mohler et al.