metabotropic glutamate receptor


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metabotropic glutamate receptor

A G protein-coupled receptor that mediates its effects by enzyme activation.
mGluRs can be subdivided into three groups (I–III) according to their sequence similarity, transduction mechanism and pharmacological profile.
References in periodicals archive ?
According to the company, the glutamate receptors, in particular the metabotropic glutamate receptor 1 (GRM1), are expressed on several tumors and plays a critical role in tumor metabolism.
Therapeutic potential of metabotropic glutamate receptor modulators.
Global Markets Direct's, 'Metabotropic Glutamate Receptor 3 (mGluR3 or GRM3 or GPRC1C or MGLUR3) - Pipeline Review, H1 2016', provides in depth analysis on Metabotropic Glutamate Receptor 3 (mGluR3 or GRM3 or GPRC1C or MGLUR3) targeted pipeline therapeutics.
1996) Presynaptic calcium current modulation by a metabotropic glutamate receptor.
Among pipeline products, the report particularly details pipeline programs targeting the following factors: LRRK2, progranulin, glial cell-derived neurotrophic factor, cerebral dopamine neurotrophic factor, tyrosine receptor kinase B, mesencephalic astrocyte-derived neurotrophic factor, metabotropic glutamate receptor, DJ-1, C-jun-N-terminal kinases, reactive oxygen species, heat shock proteins, heat shock transcription factor, growth hormone secretagogue receptor, protein phosphasate 2A, and cytochrome P450 2D6.
This allows another protein, mGluRS Metabotropic Glutamate Receptor, to function unchecked resulting in over activity in the brain.
Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus.
Metabotropic glutamate receptor mediated long-term depression in developing hippocampus.
While there are different types of receptors at the synapse, abnormally high signalling through one particular class -- the group 1 metabotropic glutamate receptor -- is implicated in many of the symptoms seen in FXS.
Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8.
A drug that targets the gene Bear's team studied, which makes a protein called metabotropic glutamate receptor 5 (mGluR5), might be able to restore some mental functioning by improving this signaling, he says.