Among pipeline products, the report particularly details pipeline programs targeting the following factors: LRRK2, progranulin, glial cell-derived neurotrophic factor, cerebral dopamine neurotrophic factor, tyrosine receptor kinase B, mesencephalic astrocyte-derived neurotrophic factor, metabotropic glutamate receptor
, DJ-1, C-jun-N-terminal kinases, reactive oxygen species, heat shock proteins, heat shock transcription factor, growth hormone secretagogue receptor, protein phosphasate 2A, and cytochrome P450 2D6.
Heptares Therapeutics, the leading GPCR structure-guided drug discovery and development company, announces the publication of a scientific article describing the first high-resolution X-ray crystal structure of the transmembrane domain of the metabotropic glutamate receptor
Simultaneously, metabotropic glutamate receptor
1 mRNA and protein expressions were upregulated in the rat hippocampus.
While there are different types of receptors at the synapse, abnormally high signalling through one particular class -- the group 1 metabotropic glutamate receptor
-- is implicated in many of the symptoms seen in FXS.
Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor
A drug that targets the gene Bear's team studied, which makes a protein called metabotropic glutamate receptor
5 (mGluR5), might be able to restore some mental functioning by improving this signaling, he says.
Augmented motor activity and reduced striatal preprodynorphin mRNA induction in response to acute amphetamine administration in metabotropic glutamate receptor
1 knockout mice.
6 Metabotropic Glutamate 2/3 Receptor Agonists and Positive Allosteric Modulators of Metabotropic Glutamate Receptor
2 as Novel Agents for the Treatment of Schizophrenia
The Glutamate Receptor Modulators and Therapeutics Agents patent (US #8614205) identifies a novel family of metabotropic glutamate receptor
modulators as potential therapeutic agents for pain, neurological disorders and psychiatric illnesses.
The researchers found that with age, the presenilin mutant - the Alzheimer's fruit fly model-lost the ability to learn and remember and that this age-onset cognitive deficit could be prevented by treating the flies with drugs, or by genetic manipulations that reduce metabotropic glutamate receptor
For example, both an antagonist of metabotropic glutamate receptor
5 (mGluR5) and agonists of mGluR2 and mGluR3, all of which decrease glutamate function, blocked cue-induced reinstatement of alcohol self-administration (Schroeder et al.
neurologists expect Novartis's mavoglurant, a metabotropic glutamate receptor
5 antagonist in development for PD dyskinesias, will earn a modest estimated 25 percent patient share of their intermediate through advanced PD patients.