Attenuation of behavioral effects of cocaine by the metabotropic
glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine.
N-acetylcysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic
sup], Enhanced density of postsynaptic metabotropic
glutamate 5 (mGlu5) receptor and specific combination with the striatum and posterior putamen observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned macaque models could contribute to the pathogenesis of LIDs in PD.
The report provides comprehensive information on the Metabotropic
Glutamate Receptor 3 (mGluR3 or GRM3 or GPRC1C or MGLUR3), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic
glutamate receptor 5 activity," Biochimie, vol.
Pretreatment with a single dose of gabapentin blocked dose-dependently the development of hyperalgesia (which is NMDA-mediated) and tactile allodynia (Which is AMPA and metabotropic
receptor-mediated) for up to two days in a rat model of postoperative pain, while giving gabapentin one hour after intervention reduced symptoms for only 3 hr (Field et al.
18) Epigenetic regulation of type-2 metabotropic
glutamate (mGluR2) receptors have recently been linked to antidepressant efficacy.
NYSE MKT: MDGN) has acquired neuroFix Therapeutics, LLC, the developer of NFC-1, a first-in-class, non-stimulant metabotropic
glutamate receptor (mGluR) neuromodulator, the company said.
The host laboratory has developed a powerful new optopharmacological tool: a selective photoswitchable modulator of metabotropic
glutamate receptors (mGluR).
Among pipeline products, the report particularly details pipeline programs targeting the following factors: LRRK2, progranulin, glial cell-derived neurotrophic factor, cerebral dopamine neurotrophic factor, tyrosine receptor kinase B, mesencephalic astrocyte-derived neurotrophic factor, metabotropic
glutamate receptor, DJ-1, C-jun-N-terminal kinases, reactive oxygen species, heat shock proteins, heat shock transcription factor, growth hormone secretagogue receptor, protein phosphasate 2A, and cytochrome P450 2D6.
Twenty chapters are divided into four parts: neurons: excitable and secretory cells that establish synapses; ionotropic and metabotropic
receptors in synaptic transmission; somato-dendritic processing and plasticity of postsynaptic potentials; the hippocampal network.
glutamate receptors (mGluRs) are G-protein coupled receptors that contain the binding site for glutamate, and mGlu4, specifically, is localized to presynaptic terminals in a region of the brain called the substantia nigra pars compacta (SNpc).