metabolic bone disease


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Related to metabolic bone disease: osteoporosis

metabolic bone disease

Any defect in bone absorption or deposition that alters the PTH/calcium-phosphate/vitamin D axis, often with increased bone fragility.
 
Aetiology
• Acquired—Fibrous dysplasia, Langerhans cell histiocytosis/histiocytosis X, acromegaly, corticosteroid therapy, heparin, hyperparathyroidism, hyperthyroidism, rickets, immobilisation syndrome, bone metastases, metabolic disease.
• Congenital—Ehlers-Danlos syndrome, homocystinuria, hypophosphatasia, Marfan syndrome, osteogenesis imperfecta, osteoporosis, Paget’s disease of bone (osteitis deformans).
 
Diagnostic workup
Measure Ca2+, PO4–, PTH, other hormones, bone biopsy, tetracycline test.

metabolic bone disease

Any defect in bone absorption or deposition that alters the PTH/calcium-phosphate/vitamin D axis, often with ↑ bone fragility Etiology Fibrous dysplasia, Langerhans' cell histiocytosis/histiocytosis X, acromegaly, corticosteroid therapy, heparin, hyperparathyroidism, hyperthyroidism, rickets, immobilization syndrome, bone metastases, metabolic disease, congenital–Ehlers-Danlos syndrome, homocystinuria, hypophosphatasia, Marfan syndrome, osteogenesis imperfecta, osteoporosis, Paget's disease of bone–osteitis deformans Diagnostic workup Measure Ca2+, PO4–, PTH, other hormones, bone biopsy, tetracycline test

metabolic bone disease

bone dysmineralization, due to dietary and hormonal dysfunction, e.g. hypercalcaemia, hypocalcaemia, osteoporosis, osteomalacia and rickets, hypoparathyroidism, renal osteodystrophy and Paget's disease

metabolic

pertaining to internal metabolism.

metabolic acidemia
acidemia due to metabolic error.
metabolic bone disease
includes a range of bone diseases associated with metabolic diseases, e.g. secondary hyperparathyroidism, rickets and osteoporosis.
metabolic defect
generally an inherited defect that is present at birth, but which is not necessarily evident clinically for several months afterwards. The defect creates a metabolic error, which leads to the accumulation of end products which cause clinical signs, e.g. mannosidosis, porphyria or an exaggerated response from an end-organ, e.g. inherited goiter. See also inborn error of metabolism.
metabolic diseases
diseases in which normal metabolic processes are disturbed and a resulting absence or shortfall of a normal metabolite causes disease, e.g. hypocalcemia in cows, or an accumulation of the end products of metabolism causes a clinical illness, e.g. acetonemia of dairy cows. Many diseases in this group really have their beginnings in a nutritional deficiency state. See also production diseases.
metabolic encephalopathy
many disorders of metabolism can lead to neurologic abnormalities through alterations in electrolytes and acid-base balance, accumulation of endogenous toxins. See also encephalopathy.
metabolic error
see metabolic defect (above).
metabolic inhibition technique
a virus neutralization test in tissue culture in which phenol-red indicator is used to detect the acid metabolic products of actively metabolizing cells or the lack of metabolism when cells are infected and destroyed by the virus.
metabolic laminitis
metabolic myopathies
muscular dystrophies caused by metabolic defects; include systemic glycogenoses, deposits of a PAS-positive glycoprotein, the lipid storage disease of cats caused by carnitine deficiency.
metabolic pathways
groupings of enzymic processes leading to the synthesis or breakdown of carbohydrates, amino acids and lipids.
metabolic polymyopathy
a muscle disease associated with a metabolic disorder, e.g. hyperadrenocorticism.
metabolic polyneuropathy
a disease of the nerves associated with a metabolic disorder, e.g. uremia, diabetes mellitus or hypothyroidism.
metabolic profile
results of a spectrum of tests of metabolic functions.
metabolic profile test
metabolic rate
the rate of energy metabolism in the body. The basal metabolic rate (BMR) is the rate of energy consumption by the body when it is completely at rest.
metabolic syndrome
characterized by hypertension, insulin resistance, an abnormal plasma lipid profile, and obesity.
metabolic toxins
include histamine, other toxic amines, ketone bodies, phenols and cresols from the large intestine, which are normal end-products of metabolism and indigestion but if their normal excretion and detoxication are impeded, cause intoxication. See also toxin.
metabolic water
the water produced in the body by oxidative metabolism of food; it represents 5-10% of the body's water utilization.
References in periodicals archive ?
Severe metabolic bone disease as a long-term complication of obesity surgery.
Metabolic bone disease is present at diagnosis in patients with inflammatory bowel disease.
All 723 patients in the study had been cleared by a specialist in internal medicine for elective surgery in one of the following orthopaedic service areas: Trauma, Foot and Ankle, Sports Medicine (only ACL and/or meniscal repair), Arthroplasty (only primary total hip and knee replacement), Hand (only distal radial or ulnar fracture) and Metabolic Bone Disease (only vertebral compression fracture).
Michael Whyte, Medical/Scientific Director of the Center for Metabolic Bone Disease and Molecular Research at Shriners Hospital for Children in St.
The contributors cover embryology and the formation of bone; metabolic bone disease and osteonecrosis; leg deformities and skeletal dysplasias in children; arthritic disorders; disorders of muscles, tendons and ligaments; disorders of nerves; osteomyelitis and septic arthritis; tumors and like conditions, fractures and trauma in adults and children, amputations and rehabilitation.
New markers of bone metabolism: clinical use in metabolic bone disease [Review].
KAI Pharmaceuticals is a privately held, venture-backed drug discovery and development company with clinical-stage programs addressing significant and unmet patient needs in cardiovascular disease, metabolic bone disease and pain.
Osteoporosis and Metabolic Bone Disease Center) presents an illustrated guide of eight chapters on the diagnosis and treatment of endocrine and metabolic disorders for physicians, residents, trainee endocrinologists, and medical students.
The text covers all categories of musculoskeletal disease, such as trauma, tumors, joint disease, endocrine and metabolic bone disease, infections, congenital and developmental conditions, and musculoskeletal manifestations of systemic disease.
Urinary measurement of DPD has also been used to evaluate response to treatment in metabolic bone disease (23-28) and has been correlated with radiolabeled calcium and bone scan data (4,15).
In fact, osteoporosis is the most prevalent metabolic bone disease in developed countries, including the United States, particularly for Caucasian and Asian women1.
A group of surgeons mostly from the US discuss general principles, the various modalities commonly used for patient evaluation and the evaluation and treatment of musculoskeletal infection, metabolic bone disease, and musculoskeletal oncology, as well as rheumatological diseases affecting the musculoskeletal system, orthopedic trauma, and the treatment of sports medicine patients.